Hepatocellular Carcinoma: Molecular Mechanisms, Diagnosis and Therapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 21
Special Issue Editor
Special Issue Information
Dear Colleagues,
Liver cancer, with 80% of cases arising in individuals with chronic liver disease, poses a grave prognosis. A comprehensive understanding of Hepatocellular Carcinoma (HCC) pathogenesis requires an exploration of the intricacies within the chronically diseased liver—a dynamic environment fostering inflammation and stress, providing a substrate for HCC emergence. Primary liver cancers, classified as HCC and the aggressive Cholangiocarcinoma (CCA), present a challenge due to their vast heterogeneity, ranging from pure HCC to pure CCA, with the degree of cholangiocytic characteristics correlating with aggressiveness. Progression and treatment responses unveil adaptability, often resulting in resistance and amplification of cholangiocytic traits. The elusive mechanisms driving cellular plasticity and phenotypic transitions in HCC cells necessitate unraveling for effective intervention. Our Special Issue delves into hepatocellular cancer pathogenesis at the cellular and molecular levels, emphasizing diagnosis, classification, and emerging treatments. Enriching our exploration, we discuss advances in personalized medicine, exploring how molecular profiling and individualized therapies shape liver cancer management. A dedicated section explores immunotherapeutic strategies, including recent trials, successes, and challenges. Mechanisms of drug resistance are examined, alongside strategies like combination therapies and novel drug delivery methods. Integrating perspectives from basic research and clinical practice, we showcase collaborative studies bridging the gap between lab findings and real-world applications. Emphasizing patient-centric approaches, we discuss outcomes, survivorship programs, and supportive care. This concise overview captures the current state of research while spotlighting promising directions for future investigation and clinical application.
Dr. Mingdian Tan
Guest Editor
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Keywords
- liver cancer
- hepatocellular carcinoma
- pathogenesis
- diagnosis
- classification
- treatment
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