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Cancers
Special Issues
Clinical PET Studies in Neuro-Oncology (Volume II)
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Clinical PET Studies in Neuro-Oncology (Volume II)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 1 December 2024 | Viewed by 343

Special Issue Editor

Prof. Dr. Antoine Verger

E-Mail Website
Guest Editor
1. Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Université de Lorraine, F-54000 Nancy, France
2. IADI UMR 1254, INSERM, Université de Lorraine, F-54000 Nancy, France
Interests: PET imaging; amino-acid radiotracers; neuro-oncology; glioma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

PET imaging is currently recommended as an adjunct to MRI for the assessment of brain tumors. The present Special Issue will focus on PET brain tumor assessment at different stages of the disease, including initial diagnosis, treatment planification, and follow-up studies in clinical practice. All types of brain tumors will be covered, including glioma, brain metastases, meningioma, and primary cerebral lymphoma. Specific attention will be paid to clinical studies with translational research to monitor peptide receptor radionuclide therapy. All of the available PET radiotracers that are useful in neuro-oncology clinical practice will be welcome, including FDG, amino acid radiotracers, DOTATOC PET imaging, and TSPO imaging. The objective of this Special Issue is to provide a complete and comprehensive overview of the potential of PET imaging in neuro-oncology to neuro-oncologists, neurosurgeons, radiologists, and nuclear physicians.

Prof. Dr. Antoine Verger
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • PET
  • neuro-oncology
  • glioma
  • meningioma
  • lymphoma
  • brain metastasis
  • amino acid radiotracer
  • peptide receptor radionuclide therapy
  • DOTATOC
  • FDG
  • TSPO

Published Papers (1 paper)

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Research

10 pages, 2244 KiB  
Article
The Value of PET/CT in Particle Therapy Planning of Various Tumors with SSTR2 Receptor Expression: Comparative Interobserver Study
by Carola Lütgendorf-Caucig, Patricia Wieland, Eugen Hug, Birgit Flechl, Slavisa Tubin, Razvan Galalae, Petra Georg, Piero Fossati, Marta Mumot, Semi Harrabi, Irina Pradler and Maciej J. Pelak
Cancers 2024, 16(10), 1877; https://doi.org/10.3390/cancers16101877 - 15 May 2024
Viewed by 173
Abstract
The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including [...] Read more.
The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including 30 meningiomas, 12 PitNET and 5 SBPGL. Four independent observers were instructed to contour the macroscopic tumor volume on planning MRI and then reassess their volumes with the additional information from DOTA-PET/CT. The conformity between observers and reference volumes was assessed. In total, 46 cases (97.9%) were DOTA-avid and included in the final analysis. In eight cases, PET/CT additional tumor volume was identified that was not detected by MRI; these PET/CT findings were potentially critical for the treatment plan in four cases. For meningiomas, the interobserver and observer to reference volume conformity indices were higher with PET/CT. For PitNET, the volumes had higher conformity between observers with MRI. With regard to SBGDL, no significant trend towards conformity with the addition of PET/CT information was observed. DOTA PET/CT supports accurate tumor recognition in meningioma and PitNET and is recommended in SSTR2-expressing tumors planned for treatment with highly conformal radiation. Full article
(This article belongs to the Special Issue Clinical PET Studies in Neuro-Oncology (Volume II))
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