Mitochondrial Uncoupling and Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: 23 November 2024 | Viewed by 123

Special Issue Editors

E-Mail Website
Guest Editor
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Interests: metabolism; physiology; nutrition; mitochondria; bioenergetics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Biotechnology and Biomolecular Sciences (BABS), University of New South Wales, Sydney, NSW 2052, Australia
Interests: liver cancer; cancer biology; cancer metabolism

Special Issue Information

Dear Colleagues,

Mitochondrial uncoupling has a nuanced role in cancer biology. On the one hand, cancer cells upregulate mitochondrial uncoupling as an antioxidant strategy to confer chemoresistance and cell survival, while on the other hand, small-molecule mitochondrial uncoupler drugs have powerful anticancer efficacy. Thus, both the inhibition of endogenous mitochondrial uncoupling (e.g., UCP2 inhibition) and the activation of exogenous mitochondrial uncoupling are anticancer strategies. Therefore, we invite submissions for this Special Issue with the aim of better understanding this conundrum regarding how mitochondrial uncoupling can be targeted for anticancer therapy. We are pleased to invite you to submit original research or review articles that are relevant to mitochondrial uncoupling or mitochondrial membrane potential in cancer biology. We welcome basic, translational, and clinical studies on all tumor types. We look forward to receiving your contributions.

Yours faithfully,

Dr. Kyle Lee Hoehn
Dr. Frances L. Byrne
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • uncoupling proteins
  • UCP2
  • mitochondrial uncouplers
  • mitochondrial membrane potential

Published Papers

This special issue is now open for submission.
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