Lymph Node Detection in Gynecological Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".
Deadline for manuscript submissions: closed (30 June 2025) | Viewed by 274
Special Issue Editor
Interests: gynecologic oncology; gynecologic surgery; laparoscopy; robotic surgery; cytore-ductive surgery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nodal staging holds a pivotal role in the treatment and prognostic evaluation of gynecological malignancies. The adoption of sentinel node biopsy (SLN) has revolutionized our surgical approach, significantly impacting the containment of surgical morbidity and providing greater detail in patient prognostication.
Concerning the SLN application, this technique is now the standard in endometrial cancer surgical staging, with high accuracy that has led to its adoption even in high-risk patients.
In 2023, the most recent guidelines on cervical cancer treatment mentioned its adoption, and, even though a pelvic lymphadenectomy is still recommended for stages higher than IA, we expect the results of SENTICOL III to provide further evidence for its use in higher stages. In vulvar cancer, the adoption of SLN can spare fragile and elderly patients from an invasive inguinal lymphadenectomy. However, a double injection procedure with a radiotracer and dye is still the standard, and advancements in this context would be beneficial.
The detection of low-volume metastasis through SLN analysis has provided further detail to surgical staging; however, the prognostic impact of especially isolated tumor cells is still debated. Moreover, the need for adjuvant treatment and the best method of administration are controversial in some contexts.
Advancements in the analysis of SLN include not only ultra-staging and immunohistochemistry but also one-step nucleic acid amplification (OSNA), inherited from breast cancer, which represents an additional innovation in this field. However, more evidence about its applicability and safety in gynecological malignancies is needed.
We cordially invite submissions from experts in the field, especially those focusing on the clinical application of sentinel node biopsy, tracers’ injection techniques, detection of low-volume metastasis, and their impact on patient prognostication.
Sincerely,
Dr. Roberto Berretta
Guest Editor
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Keywords
- sentinel node
- endometrial cancer
- cervical cancer
- vulvar cancer
- nodal staging
- ultra-staging
- isolated tumor cells
- micrometastasis
- nodal staging
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