Patient-Derived Cancer Models: Organoids, Organ-on-Chip Systems and AI-Driven Ex Vivo Platforms
A Special Issue of Cancers (ISSN 2072-6694) belonging to the section "Methods and Technologies Development".
Deadline for manuscript submissions: 31 August 2027 | Viewed by 21
Editor
Interests: cancer models; organ-on-chip; AI-driven ex vivo platforms
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Patient-derived cancer models have become a core tool in precision oncology, but the field is changing rapidly. This Special Issue will focus on new directions rather than routine drug screening. A major theme is immune-competent organoids. Instead of just measuring whether a tumor responds to a drug, these models show how tumors suppress immune cells and resist immunotherapy. This Special Issue will include studies that reconstruct the tumor microenvironment, including work involving T cells, myeloid cells, and lymph node structures. We also welcome the submission of organ-on-chip and vascularized systems. Adding perfusable blood vessels allows researchers to study drug delivery, angiogenesis, and the reasons behind the failure of cell therapies to reach solid tumors.
On the computational side, we solicit papers that include for AI and machine learning methods that predict drug response, guide drug design, and read-out results at the single-organoid resolution. Papers that combine organoids with CRISPR screens or that build large pan-cancer platforms and biobanks are particularly welcome. Finally, we encourage submissions on standardization, reproducibility, and benchmarking. Reviews, original research, and method papers are all welcome. The field needs honest reporting, including negative results, if these models are to hold up in clinical settings.
Dr. Matthias Nees
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- patient-derived organoids
- tumor-on-chip
- functional precision oncology
- AI-driven drug response
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