Special Issue "Advances in Neuropsychiatric Systemic Lupus Erythematosus"

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuropathology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Prof. Dr. Ricard Cervera
E-Mail Website
Guest Editor
Department of Autoimmune Diseases, Hospital Clinic, Barcelona, 08036 Catalonia, Spain
Interests: systemic lupus erythematosus; antiphospholipid syndrome; systemic autoimmune diseases
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Neuropsychiatric (NP) systemic lupus erythematosus (SLE) is one of the most challenging organ involvements in this condition. Unfortunately, none of the NP manifestations that occur in SLE have features that are specific for SLE; therefore, determining the correct diagnosis is a challenging and critical step in order to decide the adequate treatment of individual patients, and in the performance of research studies.

Currently, newer and more advanced neuroimaging technologies are helping in both diagnosis and follow up. Additionally, advances in our knowledge of the main pathogenetic pathways (ischemic and neuroinflammatory mechanisms) allows for a better selection of therapies (antithrombotic or anti-inflammatory/immunomodulatory drugs). Furthermore, a multidisciplinary expert team approach is, without doubt, the best strategy for managing NPSLE.

However, there are still many unmet needs in the management of NPSLE (absence of diagnostic biomarkers, lack of novel therapies, paucity of clinical trials, etc.), which will be the scope of the present Special Issue of Brain Sciences.

Prof. Dr. Ricard Cervera
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Neuropsychiatric systemic lupus erythematosus
  • Neurolupus
  • Antiphospholipid syndrome
  • Neuroimaging

Published Papers (1 paper)

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Research

Article
Structural Changes on MRI Demonstrate Specific Cerebellar Involvement in SLE Patients—A VBM Study
Brain Sci. 2021, 11(4), 510; https://doi.org/10.3390/brainsci11040510 - 16 Apr 2021
Viewed by 637
Abstract
The purpose of this study is to investigate possible differences in brain structure, as measured by T1-weighted MRI, between patients with systemic lupus erythematosus (SLE) and healthy controls (HC), and whether any observed differences were in turn more severe in SLE patients with [...] Read more.
The purpose of this study is to investigate possible differences in brain structure, as measured by T1-weighted MRI, between patients with systemic lupus erythematosus (SLE) and healthy controls (HC), and whether any observed differences were in turn more severe in SLE patients with neuropsychiatric manifestations (NPSLE) than those without (non-NPSLE). Structural T1-weighted MRI was performed on 69 female SLE patients (mean age = 35.8 years, range = 18–51 years) and 24 age-matched female HC (mean age = 36.8 years, range = 23–52 years) in conjunction with neuropsychological assessment using the CNS Vital Signs test battery. T1-weighted images were preprocessed and analyzed by FSL-VBM. The results show that SLE patients had lower grey matter probability values than the control group in the VIIIa of the cerebellum bilaterally, a region that has previously been implied in sensorimotor processing in human and non-human primates. No structural differences for this region were found between NPSLE and non-NPSLE patients. VBM values from the VIIIa region showed a weak positive correlation with the psychomotor speed domain from CNS Vital Signs (p = 0.05, r = 0.21), which is in line with its presumed role as a sensorimotor processing area. Full article
(This article belongs to the Special Issue Advances in Neuropsychiatric Systemic Lupus Erythematosus)
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