Recent Advances in CNS Repair and Regeneration

Dear Colleagues,

Injuries to the central nervous system (CNS) are a critical public health concern that result in a large number of deaths and significant impairments leading to permanent disabilities. Current studies estimate a worldwide annual incidence in the range of 500–800 per 100,000 population per year, accounting for nearly 12% of the total global disability-adjusted life years. CNS neurons of the brain, spinal cord and optic nerve are particularly susceptible to damage, and as a result of both extrinsic and intrinsic factors, CNS neurons have a limited capacity to regenerate their axons. 

The aim of this Special Issue is to give an overview of the most recent advances in CNS repair and regeneration, with a particular focus on the molecular mechanisms of neuronal damage and axon regeneration and their role in promoting the restoration of function. 

Furthermore, this Special Issue aims to take into account recent advances in biomarkers that enable CNS injury stratification, and neuroethologies which enable functional restoration. We are soliciting only high-quality review articles for this Issue.

Prof. Dr. Zubair Ahmed
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• CNS injury
• CNS axon regeneration
• spinal cord injury
• traumatic brain injury
• optic nerve injury
• regeneration associated genes (RAGs)
• extrinsic and intrinsic factors
• post-injury plasticity in the CNS
• neurorehabilitation
• neurotechnologies