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Brain Sciences
Special Issues
Current Perspectives on the Management of Acute-Phase Ischemic Stroke
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Current Perspectives on the Management of Acute-Phase Ischemic Stroke

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurorehabilitation".

Deadline for manuscript submissions: closed (16 May 2025) | Viewed by 887

Special Issue Editors

Dr. Stefano Caproni

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Guest Editor
Neurology and Stroke Unit, Neuroscience Department, “S. Maria” University Hospital, 05100 Terni, Italy
Interests: stroke; neurocritical care; ischemic stroke; vascular diseases
Dr. Ettore Nicolini

E-Mail Website
Guest Editor Assistant
Emergency Department, Stroke Unit, Castels Hospital, Via Nettunense Km 11, 00040 Rome, Italy
Interests: ischemic stroke; vascular diseases; endovascular treatment; acute stroke
Dr. Soffien Ajmi

E-Mail Website
Guest Editor Assistant
Neurology Research Group, Department of Neurology, Stavanger University Hospital, 4011 Stavanger, Norway
Interests: stroke; vascular diseases; endovascular treatment; healthcare

Special Issue Information

Dear Colleagues,

Acute ischemic stroke (AIS) is a complex condition requiring immediate and thorough treatment. The most effective therapy for AIS patients is currently endovascular thrombectomy (EVT), either alone or in combination with intravenous thrombolysis. However, this time-sensitive treatment is only suitable for a limited number of patients. Despite the need for significant advancements in the management of AIS, no alternative therapies have been approved for clinical use so far. Nevertheless, there is optimism, as ongoing clinical research into new therapies is showing promising results. These emerging drugs target and mitigate some of the molecular mechanisms responsible for cerebral ischemia and secondary brain damage. The aim of this Special Issue is to comprehensively explore the mechanisms and pathogenesis of AIS, as well as potential therapies that have shown, in preclinical or clinical studies, the ability to improve outcomes for AIS patients.

Dr. Stefano Caproni
Guest Editor

Dr. Ettore Nicolini
Dr. Soffien Ajmi
Guest Editor Assistants

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute ischemic stroke
  • endovascular thrombectomy
  • thrombolysis
  • clinical treatment

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Published Papers (1 paper)

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Research

14 pages, 958 KiB  
Article
Stress Hyperglycemia Is Associated with Unfavorable Outcomes After Mechanical Thrombectomy in Patients with Acute Ischemic Stroke
by Jie Gao, Xiangliang Chen, Qing Huang, Mengmeng Gu, Ye Hong and Gelin Xu
Brain Sci. 2025, 15(4), 360; https://doi.org/10.3390/brainsci15040360 - 30 Mar 2025
Viewed by 460
Abstract
Background: Stress hyperglycemia may deteriorate stroke outcomes, but its impact on the prognosis following mechanical thrombectomy remains unclear. This study aimed to evaluate the effects of stress hyperglycemia on in-hospital and 3-month outcomes in stroke patients with anterior circulation occlusion undergoing mechanical thrombectomy. [...] Read more.
Background: Stress hyperglycemia may deteriorate stroke outcomes, but its impact on the prognosis following mechanical thrombectomy remains unclear. This study aimed to evaluate the effects of stress hyperglycemia on in-hospital and 3-month outcomes in stroke patients with anterior circulation occlusion undergoing mechanical thrombectomy. Methods: A total of 415 patients who had mechanical thrombectomy in the anterior circulation were enrolled. The stress hyperglycemia ratio (SHR) was calculated as the fasting glucose to glycated hemoglobin ratio and was categorized into tertiles (i.e., SHR1–3). In-hospital and 3-month outcomes were compared using multivariable regression models. The impact of SHR stratified by diabetes status was evaluated and the predictive accuracy of the Totaled Health Risks in Vascular Events (THRIVE)-c risk score was explored with the inclusion of SHR. Results: Compared to the SHR1–2 groups, the SHR3 group exhibited significantly higher rates of 24 h symptomatic intracranial hemorrhage (adjusted odds ratio [aOR], 4.088; 95% confidence interval [CI], 1.551–10.772; p = 0.004) and 72 h early neurological deterioration (aOR, 3.505; 95% CI, 1.984–6.192; p < 0.001), while the incidence of post-stroke pneumonia did not differ significantly between the groups (aOR, 1.379; 95% CI, 0.838–2.268; p = 0.206). At three months, the SHR3 group had a worse distribution of modified Rankin scale (aOR, 2.261; 95% CI, 1.495–3.421; p < 0.001) and faced a higher risk of functional dependence (adjusted hazard ratio [aHR], 1.629; 95% CI, 1.230–2.158; p = 0.001) as well as all-cause mortality (aHR, 1.986; 95% CI, 1.235–3.194; p = 0.005). The adverse effects of an elevated SHR were more pronounced in non-diabetic patients, and incorporating SHR significantly enhanced the predictive accuracy of the THRIVE-c score for poor stroke outcomes. Conclusions: Stress hyperglycemia could be related to the risks of in-hospital complications and 3-month poor outcomes following mechanical thrombectomy in the anterior circulation. Full article
(This article belongs to the Special Issue Current Perspectives on the Management of Acute-Phase Ischemic Stroke)
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