New Insights into Cognitive and Behavioral Neurology

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Behavioral Neuroscience".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 949

Special Issue Editor

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Guest Editor
IRCCS “Carlo Besta” Neurological Institute Foundation, Via Celoria 11, 20133 Milano, Italy
Interests: cognitive functions (e.g. declarative memory, executive functions, theory of mind, and social cognition); neuropsychology; psychopathology in neurological patients; epilepsy; brain lesions (e.g. brain tumours); neurodegenerative dementia (e.g. frontotemporal dementia, posterior cortical atrophy syndrome, Alzheimers disease); Creutzfeldt-Jakob disease (CJD)

Special Issue Information

Dear Colleagues,

Cognitive and behavioral neurology is an historical branch of neurology that deals with the brain-related bases of human cognition and behavior, and also characterizes the clinical aspects and pathophysiological mechanisms of cognitive and behavioral syndromes and treatment. Cognitive and behavioral neurology has thus undergone extensive scientific development ranging from phenomenological approaches to the investigation of specific lesions, network imbalances, metabolic alterations, and affective disorders. As a result, cognitive and behavioral neurology continuously feed into and receive input from electrophysiology, neuropsychology, neuroimaging, psychiatry, genetics, and internal medicine, representing a unique contribution to knowledge of brain–mind interaction. Furthermore, it faces humanistic sciences regarding various aspects such as mentalization, social functions, and linguistic paradigms.

This Special Issue aims to provide new insights into cognitive and behavioral neurology by gathering together original clinical research studies, experimental studies regarding the pathophysiological mechanisms of cognitive and behavioral alterations, neurodevelopment, novel assessment methodologies and treatments. Multiple and single case reports presenting highly innovative findings will also be considered. While this Special Issue is open to every type of neurological disorder, special attention will be paid to social cognition, the cultural and environmental background of behavioral syndromes, interpersonal communication and relation, insomnia, neuroanatomic correlation and brain pathologies, advanced electroencephalographic and imaging techniques, and non-pharmacological treatments.

Dr. Anna Rita Giovagnoli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cognitive and behavioral neurology
  • memory
  • executive functions
  • social cognition
  • emotion recognition
  • behavior impairment
  • psychopathology
  • neuroimaging
  • neurophysiology
  • cognitive rehabilitation

Published Papers (1 paper)

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15 pages, 509 KiB  
Fifty Years of Handedness Research: A Neurological and Methodological Update
by Anna Rita Giovagnoli and Alessandra Parisi
Brain Sci. 2024, 14(5), 418; - 24 Apr 2024
Viewed by 677
Handedness, a complex human aspect that reflects the functional lateralization of the hemispheres, also interacts with the immune system. This study aimed to expand the knowledge of the lateralization of hand, foot, and eye activities in patients with immune-mediated (IM) or other (noIM) [...] Read more.
Handedness, a complex human aspect that reflects the functional lateralization of the hemispheres, also interacts with the immune system. This study aimed to expand the knowledge of the lateralization of hand, foot, and eye activities in patients with immune-mediated (IM) or other (noIM) neurological diseases and to clarify the properties of the Edinburgh Handedness Inventory (EHI) in an Italian population. Three hundred thirty-four patients with IM or noIM diseases affecting the brain or spine and peripheral nervous system were interviewed about stressful events preceding the disease, subjective handedness, and familiarity for left-handedness or ambidexterity. The patients and 40 healthy subjects underwent EHI examination. In the whole group of participants, 24 items of the EHI were classified into five factors (Hand Transitive, Hand Refined, Hand Median, Foot, Eye), demonstrating good reliability and validity. Chronological age had a significant influence on hand and foot EHI factors and the laterality quotient (LQ), particularly on writing and painting. In the patient groups, EHI factors and the LQ were also predicted by age of disease onset, duration of disease, and family history of left-handedness or ambidexterity. No differences were found between patients and healthy subjects, but pencil use scored significantly lower in patients with IM diseases than in those with noIM brain diseases. These results demonstrate that the lateralization of hand and foot activities is not a fixed human aspect, but that it can change throughout life, especially for abstract and symbolic activities. Chronic neurological diseases can cause changes in handedness. This may explain why, unlike systemic immunological diseases, IM neurological diseases are not closely associated with left-handedness. In these patients, the long version of the EHI is appropriate for determining the lateralization of body activities to contextualize the neurological picture; therefore, these findings extend the Italian normative data sets. Full article
(This article belongs to the Special Issue New Insights into Cognitive and Behavioral Neurology)
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