Next Article in Journal
Metronidazole Encephalopathy EEG Features: A Case Report with Systematic Review of the Literature
Previous Article in Journal
Does Insomnia Exist without Hyperarousal? What Else Can There Be?
Previous Article in Special Issue
Analyzing the Open/Deep Web to Better Understand the New/Novel Psychoactive Substances (NPS) Scenarios: Suggestions from CASSANDRA and NPS.Finder Research Projects
Open AccessReview

Targeting the Orexin System for Prescription Opioid Use Disorder

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(4), 226; https://doi.org/10.3390/brainsci10040226
Received: 10 March 2020 / Revised: 7 April 2020 / Accepted: 8 April 2020 / Published: 10 April 2020
Prescription opioids are potent analgesics that are used for clinical pain management. However, the nonmedical use of these medications has emerged as a major concern because of dramatic increases in abuse and overdose. Therefore, effective strategies to prevent prescription opioid use disorder are urgently needed. The orexin system has been implicated in the regulation of motivation, arousal, and stress, making this system a promising target for the treatment of substance use disorder. This review discusses recent preclinical studies that suggest that orexin receptor blockade could be beneficial for the treatment of prescription opioid use disorder. View Full-Text
Keywords: orexin; prescription opioid use disorder; oxycodone; remifentanil; fentanyl orexin; prescription opioid use disorder; oxycodone; remifentanil; fentanyl
MDPI and ACS Style

Matzeu, A.; Martin-Fardon, R. Targeting the Orexin System for Prescription Opioid Use Disorder. Brain Sci. 2020, 10, 226.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop