Clinical Research on Neurological Rehabilitation After Stroke

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurorehabilitation".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 1065

Special Issue Editor


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Guest Editor
Department of Physical Therapy, College of Rehabilitation Sciences, Daegu University, Gyeongsan 38453, Gyeongbuk, Republic of Korea
Interests: physical rehabilitation; gait; physiotherapy; stroke

Special Issue Information

Dear Colleagues,

Stroke remains a leading cause of long-term disability worldwide, placing a significant burden on individuals, families, and healthcare systems. Advances in neurological rehabilitation play a vital role in improving functional recovery and enhancing quality of life for stroke survivors. This Special Issue, "Clinical Research on Neurological Rehabilitation After Stroke," aims to highlight recent developments, innovative therapeutic approaches, and emerging technologies in stroke rehabilitation. We welcome original clinical studies, randomized controlled trials, case reports, and systematic reviews that address interventions such as physical therapy, occupational therapy, neuromodulation, robotics, virtual reality, and cognitive rehabilitation. Additionally, we encourage submissions focusing on novel assessment tools, biomarkers for recovery prediction, and strategies for personalizing rehabilitation programs. Contributions exploring the integration of multidisciplinary care and long-term community reintegration are also of interest. Through this Special Issue, we seek to provide a comprehensive and up-to-date understanding of effective clinical practices in stroke rehabilitation and to foster international collaboration among researchers and clinicians working in this critical field.

Dr. Myoung-Kwon Kim
Guest Editor

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Keywords

  • stroke rehabilitation
  • neurological recovery
  • physical therapy
  • cognitive rehabilitation
  • neuroplasticity
  • functional outcomes
  • assistive technology
  • virtual reality therapy
  • Parkinson’s disease rehabilitation

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Published Papers (1 paper)

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20 pages, 966 KB  
Systematic Review
Effectiveness of AI-Assisted Digital Therapies for Post-Stroke Aphasia Rehabilitation: A Systematic Review
by Yamil Liscano, Lina Marcela Bernal and Jhony Alejandro Díaz Vallejo
Brain Sci. 2025, 15(9), 1007; https://doi.org/10.3390/brainsci15091007 - 18 Sep 2025
Viewed by 937
Abstract
Background: Traditional aphasia therapy is often limited by insufficient dosage, a barrier that AI-assisted digital therapies are poised to overcome. However, it remains unclear whether gains on specific tasks translate to functional, real-world communication. This systematic review evaluates the effectiveness of these novel [...] Read more.
Background: Traditional aphasia therapy is often limited by insufficient dosage, a barrier that AI-assisted digital therapies are poised to overcome. However, it remains unclear whether gains on specific tasks translate to functional, real-world communication. This systematic review evaluates the effectiveness of these novel interventions and investigates the potential for a “generalization gap” when compared to conventional treatments for post-stroke aphasia rehabilitation. Methods: Following PRISMA guidelines, we systematically reviewed randomized controlled trials (2010–2024) from six databases. We included studies examining AI-powered digital platforms for adults with chronic post-stroke apha-sia that reported standardized language outcomes. Results: Our analysis of five trials (n = 366) shows that AI-assisted therapies successfully deliver high-dose interventions, leading to significant improvements in trained language skills, including word retrieval (up to 16.4% gain) and auditory comprehension. However, a critical “generalization gap” was consistently identified: these impairment-level gains rarely transferred to functional, real-world communication. Conclusions: AI-assisted digital therapies effectively solve the dosage problem in aphasia care and improve specific linguistic deficits. Their primary limitation is the failure to generalize skills to everyday use. Future platforms must therefore be strategically redesigned to incorporate therapeutic principles that explicitly target the transfer of skills, bridging the gap between clinical improvement and functional communication. Full article
(This article belongs to the Special Issue Clinical Research on Neurological Rehabilitation After Stroke)
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