Neuroimmunology: Past, Present, and Promise

Dear Colleagues,

Neuro-immune axis dysfunction is involved in several neurodegenerative disorders. In contrast to previous neuroimmunological studies, which focused mainly on classical neuroinflammatory disorders, such as multiple sclerosis and infections, there is strong evidence to suggest that the immune response contributes to a wide range of neurological disorders, also including neurodegenerative diseases, neuropsychiatric disorders, peripheral nervous system and neuro‐oncological conditions, as well as ageing.

Technological advances allow for in-depth study of how the immune system influences the nervous system during development and ageing, and how such responses contribute to disease as well as regeneration and repair.

As the average age increased, neuroinflammation has become an alarming global cause of neurological disorders, which rank first in causing morbidity worldwide.  

Future perspectives, including epigenomic and epigenetic studies, as well as the combination of transcriptomics and metabolomics approaches, offer the potential to push many areas of neuroimmunology.

Multi-omics analysis is being recently used for neurodegenerative diseases, because multi-omics technology includes multiple molecular profiling, metadata, and big data processing with informatics and computer science, so it is possible to provide new macroscopic, as well as microscopic, insights for innovative diagnostic and therapeutic approaches.

Such an understanding of neuroimmunology will open up new opportunities for therapeutic approaches to manipulate neuroinflammation.

Therefore, the main purpose of this special edition is to publish the significant advances in research on neuroimmune interplay and modulation, with special reference to pathologies related to neuroinflammation.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

1. The Neuroimmunology in neurodegenerative disorders;
2. Immune mechanisms (how the human nervous system and immune systems interact);
3. Clinical neuroimmunology research;
4. Neuroimmunological aspects of health and diseases;
5. Developments in the immunotherapy of neurological disorders;
6. Epigenomic.

I/We look forward to receiving your contributions.

Dr. Maria Elsa Gambuzza
Guest Editor

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