The Link Between Traumatic Brain Injury (TBI) and Neurodegeneration
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 826
Special Issue Editors
Interests: neurodegeneration; brain trauma; synaptic plasticity; glutamatergic transmission; neurophysiology
Special Issues, Collections and Topics in MDPI journals
Interests: acute brain injuries; traumatic brain injury; cellular communication; cortical spreading depression; neurocritical care
Special Issue Information
Dear Colleagues,
Traumatic Brain Injury and Neurodegeneration
Traumatic brain injury (TBI) is a complex neurological disorder that initiates a cascade of pathological events, eventually leading to long-term neurodegeneration. While significant progress has been made in understanding the underlying mechanisms, substantial knowledge gaps remain regarding this condition’s pathogenesis and treatment.
This Special Issue aims to bring together clinical and basic researchers to present the latest findings in the field of TBI and neurodegeneration. Through a wide range of topics, we seek to foster interdisciplinary collaboration and stimulate the development of novel therapeutic strategies.
The topics to be considered include the following:
- Molecular and cellular mechanisms: Exploring the molecular and cellular processes underlying brain injury and repair after TBI, including inflammation, oxidative stress, mitochondrial dysfunction, apoptosis, brain edema, and spreading depression;
- Role of glial cells: Analyzing the contribution of astrocytes, microglia, and oligodendrocytes to the pathogenesis and progression of TBI, as well as their potential as therapeutic targets;
- Connections between TBI and neurodegenerative diseases: Exploring the similarities and differences between TBI and neurodegenerative diseases such as Alzheimer’s and Parkinson’s and how TBI may increase the risk of developing these diseases;
- Biomarkers and diagnosis: Developing and validating biomarkers for the early detection and monitoring of TBI progression, including neurodegeneration, developing and using imaging techniques to assess brain damage;
- Treatment and rehabilitation: Evaluating existing pharmacological and non-pharmacological therapies for treating TBI and exploring new therapeutic strategies, including cell therapy, brain stimulation, and neurocognitive rehabilitation;
- Long-term impact and quality of life: Analyzing the long-term consequences of TBI on cognitive, emotional, and social function and developing interventions to improve patients’ quality of life.
We invite researchers from diverse disciplines to submit their work, including the following:
- Basic neuroscientists;
- Neurologists;
- Neurosurgeons;
- Neurocritical care physicians;
- Psychiatrists;
- Rehabilitation specialists;
- Epidemiologists;
- Biomedical engineers.
By bringing together experts from different fields, this Special Issue will provide a comprehensive overview of TBI and its sequelae, fostering the exchange of ideas to accelerate the development of new therapies and improve the lives of individuals affected by this injury.
This Special Issue is open to publications in the format of reviews, original articles, and clinical cases on a non-exclusive basis.
Dr. Waldo Cerpa
Dr. Maximiliano Rovegno
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurodegeneration
- acute brain injuries
- brain trauma
- spreading depression
- synaptic plasticity
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