Fatigue in Multiple Sclerosis: Current Concepts and Future Challenges

Dear Colleagues,

Fatigue is a frequent and devastating complaint in patients with multiple sclerosis (MS). It affects up to 90% of patients at some point during their disease course and can drastically alter their quality of life. To date, the underlying mechanisms of MS fatigue remain to be clarified. Its evaluation mainly relies on subjective scales which renders the symptom difficult to be described by patients or characterized by physicians. The available approved therapeutic options yield unsatisfactory outcomes in a large number of cases and are challenged by several side effects. Alternative therapies have been explored in this context but their effects remain to be confirmed in large scale studies. Facing all these limitations, more research is needed in an attempt to improve the clinical characterization of the symptom, understand its pathophysiology and optimize its management.

For all these reasons, this Special Issue focuses on, but is not limited to, reviews and original studies addressing fatigue pathophysiology, evaluation and management. This includes works addressing the clinical, neuropsychological, physiological, molecular and imaging substrates of MS fatigue. Studies applying pharmaceutical or alternative interventions are of great interest.

Dr. Samar S. Ayache
Dr. Moussa A. Chalah
Dr. Simranjit Sidhu
Guest Editors

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