Special Issue "Borderline Personality Disorder: Psychopathology, Diagnosis and Treatment"

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Clinical Neuroscience".

Deadline for manuscript submissions: 15 July 2019

Special Issue Editor

Guest Editor
Dr. Robert Dudas

Visiting Researcher, Department of Psychiatry, University of Cambridge, UK
Hon. Senior Lecturer, University of East Anglia, Norwich, UK
Consultant Psychiatrist, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK
ARC, Douglas House, 18D Trumpington Road, Cambridge, CB2 8AH, UK
Website | E-Mail
Interests: borderline personality disorder; perinatal mood disorders; autism; dementia; fMRI

Special Issue Information

Dear Colleagues,

Borderline Personality Disorder (BPD) is a severe mental disorder, characterized by pronounced disturbances in emotion processing and regulation, identity alterations, dissociation, impulsivity, and interpersonal problems. BPD affects about 1.3% of the general population, with a lifetime prevalence of approximately 3–5.9%. Current conceptualizations suggest that a complex interplay of genetic, neurobiological predispositions, adverse life events (e.g., interpersonal trauma), maladaptive cognitive schemata (negative beliefs about the self and others), and dysfunctional stress coping contributes to the development and maintenance of the disorder. With respect to the neurobiology, a growing number of neuroimaging studies observed structural and functional abnormalities in a fronto-limbic brain regions (including amygdala, insula, anterior cingulate cortex, medial frontal cortex, orbitofrontal cortex, and dorsolateral prefrontal cortex) and in regions of the default-mode network, which may underlie disturbed emotion processing in BPD. More and more studies have also provided evidence for altered functional connectivity in large-scale brain networks during rest and during emotion processing in BPD. This Special Issue encourages submissions, which provide further insight into the psychopathology, diagnosis, and treatment of BPD. This includes original articles based on experimental research and neuroimaging studies applying novel techniques, as well as review articles and meta-analyses, which may enhance the understanding of processes and mechanisms underlying and maintaining BPD.

Dr. Robert Dudas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 850 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Borderline Personality Disorder
  • Emotion Dysregulation
  • Dissociation
  • Self-harming
  • Functional Magnetic Resonance Imaging
  • Neuroimaging
  • Brain function
  • Diagnosis
  • Treatment

Published Papers (1 paper)

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Open AccessReview
The Modulating Role of Self-Referential Stimuli and Processes in the Effect of Stress and Negative Emotion on Inhibition Processes in Borderline Personality Disorder: Proposition of a Model to Integrate the Self-Concept and Inhibition Processes
Brain Sci. 2019, 9(4), 77; https://doi.org/10.3390/brainsci9040077
Received: 22 February 2019 / Revised: 18 March 2019 / Accepted: 27 March 2019 / Published: 30 March 2019
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Impulsivity is an important clinical and diagnostic feature of borderline personality disorder (BPD). Even though it has been reported that BPD individuals’ inhibition performance is significantly reduced in the context of negative emotion or stress, this literature shows mixed results, raising questions about [...] Read more.
Impulsivity is an important clinical and diagnostic feature of borderline personality disorder (BPD). Even though it has been reported that BPD individuals’ inhibition performance is significantly reduced in the context of negative emotion or stress, this literature shows mixed results, raising questions about the possible role played by other factors. Winter (2016) proposed that negative emotion stimuli can be more disruptive for BPD individuals’ attention control performance because they induce higher distractibility self-referential processes. This article aimed to systematically review the literature regarding the effect of stress and negative emotions on three main inhibition processes—prepotent response inhibition, resistance to distractor interference, and resistance to proactive interference—in BPD and to verify the putative modulating role of self-referential stimuli and processes on these inhibition processes. All English and French experimental studies published until August 2018 were searched in PsychINFO and PubMED databases. The following keywords were used: “borderline* AND inhibit* OR interference* OR forget* OR task* AND emotion* OR stress* OR affect*”. A total of 1215 articles were included in the study. After full text revision, twenty-six papers were selected for review. The results of this review indicate that when stimuli or procedures involve self-reference stimuli or processes, BPD individuals’ performance seems to be more disrupted in all three inhibition processes. A model based on Winter’s and Kernberg’s models is proposed with the aim of integrating the self-concept with inhibition processes in BPD. Full article

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