Early Diagnosis and Intervention in Alzheimer's Disease

Dear Colleagues,

Alzheimer’s disease (AD) is a neurodegenerative brain disease and the leading cause of dementia. In most affected people, symptoms first occur in their mid-60s or later. Changes at the cellular level can occur decades before symptom onset, and several years before the first symptoms, macroscopic alterations of brain structure can be observed. A key goal in the prevention and treatment of Alzheimer’s disease is therefore the development of biomarkers that allow an early detection of pathophysiological changes related to AD.

Promising research shows that the risk of Alzheimer’s and other dementias can be reduced by lifestyle modifications and potentially also by pharmacological interventions. To allow for early intervention and preserve cognitive performance, it is important to detect Alzheimer's disease within the pre-clinical stage and to initiate potential interventions before the onset of clinically overt cognitive decline.

This special issue of Brain Sciences is devoted to intercepting patients with Alzheimer's pathology early in order to develop preventive and therapeutic approaches. We especially encourage submissions concerning the pharmacological as well as non-pharmacological interventions, but contributions related to novel or refined approaches to early detection are also welcome.

Prof. Jens Wiltfang
Dr. Björn H Schott
Guest Editors

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