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Brain Sciences
Special Issues
The Biomarkers, Symptoms, and Treatment of Multiple Sclerosis
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The Biomarkers, Symptoms, and Treatment of Multiple Sclerosis

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 1488

Special Issue Editor

Dr. Clara Grazia Chisari

E-Mail Website
Guest Editor
Department of Systems Medicine, Università degli Studi di Roma "Tor Vergata", Rome, Italy
Interests: multiple sclerosis; amyotrophic lateral sclerosis; neuromyelitis optica; cefalalgia; neuro-ophthalmology; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Multiple sclerosis (MS) is a persistent autoimmune neurodegenerative condition marked by an intricate clinical progression involving inflammation, demyelination, and axonal degeneration. Assessing relapse rates, disability progression, and lesion load via MRI helps identify disease activity and treatment responses. However, the utilization of clinical and imaging biomarkers falls short in enabling individual characterization and prediction. Thus, blood and cerebrospinal fluid (CSF) biomarkers related to axonal and neuronal damage, glial dysfunction, demyelination, and inflammation have been explored as actionable indicators for MS, shedding light on this disease's underlying pathology. Nevertheless, the integration of molecular biomarkers into clinical practice is made challenging by the prolonged validation process and the considerable time required for their implementation.

The aim of the current Special Issue is to provide more insights into the use of several clinical, imaging, and molecular biomarkers for the diagnosis, prognosis, and treatment response in MS.

Authors are invited to submit original research articles and reviews that address a broad range of topics, including the validation of current MS biomarkers, the application of more advanced screening technologies (e.g., gene expression and autoantibody arrays, microRNAs, and circulating microvesicles/exosomes), and the discovery of potential molecular biomarkers derived from blood or CSF samples for monitoring the impact of MS treatment in a clinical setting.

Dr. Clara Grazia Chisari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multiple sclerosis
  • progression
  • disease activity
  • symptoms
  • biomarkers
  • blood
  • cerebrospinal fluid

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Published Papers (1 paper)

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Research

11 pages, 1236 KiB  
Article
Comparison between Motor Performance of People with Multiple Sclerosis during a Virtual Reality Task Practiced on Concrete and Abstract Devices: A Cross-Sectional Randomized Study
by Camila Miliani Capelini, Giulianna Mendes Ferrero, Ana Maria Canzonieri, Roger Pereira Silva, Mauricio Ossamu Bando, Renata Martins Rosa, Cintia Ramari Ferreira, Talita Dias da Silva, Alessandro Hervaldo Nicolai Ré, Marcelo Massa, Luciano Vieira de Araújo, Fernando Henrique Magalhães and Carlos Bandeira de Mello Monteiro
Brain Sci. 2024, 14(9), 916; https://doi.org/10.3390/brainsci14090916 - 12 Sep 2024
Viewed by 1053
Abstract
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system with unknown etiology, resulting in various impairments that necessitate continuous rehabilitation to enhance functionality, quality of life, and motor function, including through Virtual Reality (VR) therapy. Comparing tasks in virtual [...] Read more.
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system with unknown etiology, resulting in various impairments that necessitate continuous rehabilitation to enhance functionality, quality of life, and motor function, including through Virtual Reality (VR) therapy. Comparing tasks in virtual environments and their potential skill transfer to real-world settings could aid in optimizing treatment programs to improve motor performance in individuals with MS. This study aimed to determine whether practicing acquisition and retention phases using two distinct interfaces (concrete—Touch Screen or abstract—Kinect system) affects performance in a subsequent task using a different interface (transfer phase). A randomized clinical trial was conducted with 56 volunteers with MS and 41 controls. Participants engaged in a computer game where they burst as many bubbles as possible within 10 s per attempt. After the acquisition and retention phases, all participants switched interfaces (e.g., those using Kinect switched to Touchscreen and vice versa). Significant performance improvements were observed in both groups during the acquisition phase, which were maintained in the retention phase. Although the abstract interface was more challenging for both groups, only the MS group that practiced with the abstract interface successfully transferred their improvements to the concrete interface. Thus, despite the increased difficulty of the abstract task during practice, it led to better performance transfer when required to complete a subsequent concrete task, suggesting that abstract devices may be beneficial in clinical practice for improving motor function in people with MS. Full article
(This article belongs to the Special Issue The Biomarkers, Symptoms, and Treatment of Multiple Sclerosis)
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