Advances in Portable and Wearable Sensing Systems for Biochemical Monitoring—2nd Edition

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Wearable Biosensors".

Deadline for manuscript submissions: 20 December 2026 | Viewed by 2032

Special Issue Editor

Key Laboratory of Medical Rescue Technology and Equipment of Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University, Tianjin 300072, China
Interests: biosensors; wearable sensor; flexible biosensing; electrochemical sensor; optical biosensor; healthcare monitoring
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Special Issue Information

Dear Colleagues, 

After the success of the first volume of the Special Issue entitled “Advances in Portable and Wearable Sensing Systems for Biochemical Monitoring”, the journal’s Editorial Board, in collaboration with the Guest Editor, Dr. Yanli Lu and Dr. Zetao Chen, is launching Volume II under the same title. This Special Issue continues to explore the exciting developments and applications of portable and wearable sensing systems and any other area of biological interest.

Portable and wearable sensing technologies have rapidly evolved as promising tools for interdisciplinary research, offering low-cost, user-friendly, and real-time biochemical monitoring solutions. These systems are increasingly applied in analyzing biomarkers from biofluids like sweat, saliva, urine, lacrimal fluid, and interstitial fluid, supporting applications from chronic disease management to personalized fitness tracking.

Significant progress in this field is driven by innovations in flexible electronics, biocompatible materials, miniaturized sensing platforms, and artificial intelligence (AI). The advancements in nanomaterials, hydrogels, and microfluidic technologies have enhanced the sensitivity, stability, and practicality of these devices or systems. Furthermore, the integration of wireless communication and energy-harvesting technologies enables continuous, real-time health monitoring. The emergence of AI and machine learning further optimizes data processing, improving predictive capabilities for personalized healthcare.

This Special Issue highlights the latest advances in portable and wearable biochemical sensors, covering novel biosensor designs, flexible and self-powered systems, and their applications in point-of-care testing and smart health monitoring. We welcome contributions that address current challenges, such as long-term stability, power efficiency, biointegration, and multimodal sensing chip, and explore future directions for next-generation sensing systems. Original research articles and review papers are welcome.

We look forward to receiving your outstanding research outcomes.

Dr. Zetao Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • portable sensing systems
  • wearable sensing systems
  • flexible electronics
  • bioelectronics
  • biomaterials
  • multimodal perception
  • health monitoring

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Published Papers (2 papers)

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Research

24 pages, 3739 KB  
Article
A Portable and Highly Selective Electrochemical Sensor Based on Copper–Nickel Oxide-Decorated Ordered Mesoporous Carbon for Serotonin Detection
by Thenmozhi Rajarathinam, Sivaguru Jayaraman, Jang-Hee Yoon and Seung-Cheol Chang
Biosensors 2026, 16(4), 185; https://doi.org/10.3390/bios16040185 - 24 Mar 2026
Viewed by 646
Abstract
Electrochemical sensors are user-friendly devices designed for the rapid and straightforward detection of target analytes. Serotonin (5-hydroxytryptamine, 5-HT) is a key neurotransmitter and neuromodulator that regulates diverse neuronal processes. Using a custom-designed screen-printed carbon electrode (SPCE) incorporating ordered mesoporous carbon–bimetal oxides of Cu [...] Read more.
Electrochemical sensors are user-friendly devices designed for the rapid and straightforward detection of target analytes. Serotonin (5-hydroxytryptamine, 5-HT) is a key neurotransmitter and neuromodulator that regulates diverse neuronal processes. Using a custom-designed screen-printed carbon electrode (SPCE) incorporating ordered mesoporous carbon–bimetal oxides of Cu and Ni (CuO–NiO–OMC), rapid and real-time detection of 5-HT was achieved. The CuO–NiO–OMC structure featured highly active CuO and NiO catalytic sites that effectively promoted the irreversible oxidation of 5-HT (vs. Ag/AgCl reference electrode). The CuO–NiO–OMC/SPCE sensor, connected to a portable potentiostat, exhibited exceptional electrocatalytic performance for the oxidation of 5-HT, with a detection limit of 42.5 nM. The sensitivity was 1.56 A M−1 cm−2, and the linear dynamic range was 0.0–80.0 µM. The CuO–NiO–OMC/SPCE sensor also demonstrated outstanding selectivity in the presence of competing neurochemicals, including norepinephrine, epinephrine, dopamine, and glutamate, as well as high concentrations of tested biomolecules and inorganic ions. Furthermore, the practicality of the sensor was demonstrated using human serum and urine samples, with recovery percentages ranging from 91.1% to 98.3%. Thus, the CuO–NiO–OMC/SPCE sensor offers an effective approach for 5-HT sensing, thereby permitting molecular-level understanding of brain function. Full article
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16 pages, 2773 KB  
Article
A High-Performance and Versatile Fluorometer for Chlorophyll a Monitoring
by Tingkai Zhang, Yee Lyn Sim, Jianchao Luo and Shuming Ye
Biosensors 2025, 15(12), 787; https://doi.org/10.3390/bios15120787 - 1 Dec 2025
Cited by 3 | Viewed by 1021
Abstract
Chlorophyll a (Chl a) monitoring is vital for aquatic ecosystem assessment but is challenged by low signals and interference. Addressing this, we introduced balanced maximum entropy m-sequence modulation for Chl a fluorescence detection, developing a novel high-sensitivity sensor offered in configurations for both [...] Read more.
Chlorophyll a (Chl a) monitoring is vital for aquatic ecosystem assessment but is challenged by low signals and interference. Addressing this, we introduced balanced maximum entropy m-sequence modulation for Chl a fluorescence detection, developing a novel high-sensitivity sensor offered in configurations for both portable and deep-sea applications. The sensor achieved outstanding limits of detection (LOD) of 4.17 ng/L (fluorescein sodium, FS) and 4.82 ng/L (spinach-extracted Chl a), significantly surpassing commercial instruments. It also features a wide dynamic range (0–500 μg/L FS, R2 = 0.9983), excellent long-term stability with negligible drift, measured system response T90 < 24 s, and low power consumption (40 mA working/0.5 mA standby). Critically, a near 1:1 fluorescence response gain between FS and extracted Chl a under the sensor’s specific configuration was experimentally demonstrated, validating FS as a high-precision proxy standard and simplifying future calibration. Field experiments in West Lake confirmed the sensor’s ability to accurately track spatial variations consistent with the standard spectrophotometric method, achieving highly consistent quantitative results (within 3% relative error) at half sampling locations. In summary, the sensor developed in this study, due to its outstanding performance, promises to provide a reliable and efficient new tool for high-precision portable and deep-sea in situ chl a monitoring. Full article
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