Electrochemical Biosensing Platforms for Food, Drug and Health Safety—2nd Edition

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 984

Special Issue Editor


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Guest Editor
Department of Physical Chemistry, University of Bucharest, 030018 Bucharest, Romania
Interests: electrochemical biosensors; surface plasmon resonance biosensors; homogenous catalysis; reaction kinetics; self-assembled monolayers; surface coatings
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Special Issue Information

Dear Colleagues,

Electrochemical platforms are emerging as powerful tools for various applications in the fields of food, drug, and health. These platforms rely on the principles of electrochemistry to detect and quantify target analytes in complex matrices such as food, drugs, and biological fluids. They offer several advantages, such as high sensitivity, selectivity, and a rapid response time. In the food industry, electrochemical platforms can be used for detecting contaminants, such as pesticides, heavy metals, and foodborne pathogens, ensuring the safety and quality of food products. In the pharmaceutical industry, electrochemical platforms can be used for drug discovery, drug delivery, and monitoring drug efficacy. In the healthcare industry, electrochemical platforms can be used for disease diagnosis, monitoring biomarkers, and personalized medicine. Electrochemical platforms based on organic–inorganic hetero-nano-interfaces represent a promising avenue in the development of highly sensitive and selective biosensors. These platforms combine the advantages of organic and inorganic components, resulting in improved electrical conductivity, biocompatibility, and selectivity. Additionally, the use of organic materials in these interfaces allows for the design of functional groups that can selectively bind to target molecules, further increasing the selectivity of the sensor.

We invite contributions to our upcoming Special Issue about electrochemical biosensing platforms for food, drug, and health safety. We welcome submissions from a diverse range of fields pertaining to this topic, with particular interest in studies concerning the design, development, and application of organic–inorganic hetero-nano-interfaces in portable and miniaturized devices for the rapid detection of contaminants and pathogens.

Dr. Mihaela Puiu
Guest Editor

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Keywords

  • electrochemical bio(immuno)sensing
  • organic–inorganic hetero-nano-interfaces
  • early detection, signal amplification
  • conductive nanocomposites
  • magnetic nanoparticles
  • nanozymes

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Research

12 pages, 1960 KB  
Article
Innovative Fatty Acid-Guided Biosensor Design for Neutrophil Gelatinase, a Prognostic and Diagnostic Biomarker for Chronic Kidney Disease
by Kaustubh Jumle, Priya Paliwal, Mohamed A. M. Ali, Ravi Ranjan Kumar Niraj, Anis Ahmad Chaudhary and Manali Datta
Biosensors 2026, 16(2), 74; https://doi.org/10.3390/bios16020074 - 26 Jan 2026
Viewed by 785
Abstract
Chronic kidney disease (CKD) afflicts 850 million people worldwide, with an estimate that it is the 5th highest cause of years of life lost (YLLs). Standard confirmatory procedures for disease are blood and urine analysis with ultrasound for confirmation. Neutrophil gelatinase-associated lipocalin (NGAL) [...] Read more.
Chronic kidney disease (CKD) afflicts 850 million people worldwide, with an estimate that it is the 5th highest cause of years of life lost (YLLs). Standard confirmatory procedures for disease are blood and urine analysis with ultrasound for confirmation. Neutrophil gelatinase-associated lipocalin (NGAL) has been established as a prognostic biomarker, especially for the pre-clinical stages of CKD, thus presenting itself as a dependable predictor of the progression. With the aim of designing diagnostics, fatty acids were explored as potential biorecognition elements for the selective capture of NGAL. Three fatty acids—linoleic acid, arachidonic acid, and retinoic acid—were shortlisted as plausible candidates based on their known affinity toward lipocalin family proteins. Docking followed by molecular dynamics simulations were employed to evaluate the binding affinity and stability of each complex. Among them, linoleic acid exhibited the most favorable interaction, as evidenced by the lowest binding free energy. Subsequently, fluorescence and electrochemical techniques—square-wave voltammetry, differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectroscopy (EIS)—were systematically compared for qualitative and quantitative checking of the accuracy of NGAL detection. Amongst the electrochemical techniques, differential pulse voltammetry DPV demonstrated superior analytical performance with an LOD of 0.05 ng/mL with a sensitivity of 23.2 µA/cm2/pg. To the best of our knowledge, this is the first report of a fatty acid-based biosensor platform for NGAL detection, presenting a novel approach for CKD diagnostics. The sensitivity obtained is comparable with available NGAL detection methods yet cost-effective and robust. Full article
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