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Biosensors
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Novel Optical Fiber Sensors for Biochemical and Biological Applications
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Novel Optical Fiber Sensors for Biochemical and Biological Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 20 March 2027 | Viewed by 1761

Editors

Dr. Li-Peng Sun

E-Mail Website
Guest Editor
Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communication, Institute of Photonics Technology, Jinan University, Guangzhou 510632, China
Interests: optical fiber sensor; optical microfiber; fiber optic biosensor; fiber optic electrochemistry
Dr. Lili Liang

E-Mail Website
Guest Editor
Hebei Key Laboratory of Optical Fiber Biosensing and Communication Devices, Institute of Information Technology, Handan University, Handan 056005, China
Interests: optical fiber device; fiber sensor; biosensor; optofluidic sensor; biomarker detection; chip sensor
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Dandan Sun

E-Mail Website
Guest Editor
College of Physics and Electronic Engineering, Shanxi University, Taiyuan 030006, China
Interests: optical fiber sensors; optical fiber sensing;

Special Issue Information

Dear Colleagues,

The design and development of innovative optical fiber sensors, involving the exploration of novel optical fiber materials, structural designs, or sensing mechanisms, can enhance the sensitivity, selectivity, and stability of sensors and can be used in optical fiber sensing technology applications in biochemical and biological fields, encompassing biomedical imaging, biomolecule detection, environmental monitoring, food safety testing, and so on. Optical fiber sensors can be employed for the real-time monitoring of chemical changes in biological bodies or for detecting pollutants in the environment. Optical sensing technology can be integrated with nanotechnology, microfluidic technology, surface plasmon resonance technology, etc., which can lead to the development of more advanced sensing systems for the analysis of complex biological samples.

The Special Issue will cover a wide range of applications of optical fiber sensing technology in the chemical and biological fields. We invite researchers, scientists, and practitioners to contribute original research articles, reviews, and communications that align with the themes of this Special Issue.

Dr. Li-Peng Sun
Dr. Lili Liang
Prof. Dr. Dandan Sun
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical fiber
  • fiber optic devices
  • optical fiber sensor
  • interferometer
  • fiber grating
  • evanescent field
  • surface plasmon resonance
  • surface-enhanced Raman scattering
  • fiber optic fluorescence sensor
  • biosensor
  • biochemical sensor
  • biomedical sensor
  • fiber-optic drug delivery
  • diagnostics
  • therapy

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Published Papers (2 papers)

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20 pages, 4826 KB  
Article
Expanding Biolayer Interferometry Applications: Enhanced Accuracy, Precision, and Sensitivity in Residual Biomolecule Detection and Quantitation of Bispecifics and AAV Viral Particles
by Stuart Knowling, Kirsty McBain and David Apiyo
Biosensors 2026, 16(7), 390; https://doi.org/10.3390/bios16070390 - 18 Jul 2026
Viewed by 360
Abstract
Biolayer Interferometry (BLI) has traditionally been used for characterization of protein–protein interactions (PPI) with proteins, such as antibodies and their antigens, through kinetic and quantitation assays. Limitations, for example in sensitivity and the availability of established assay formats, have restricted its adoption across [...] Read more.
Biolayer Interferometry (BLI) has traditionally been used for characterization of protein–protein interactions (PPI) with proteins, such as antibodies and their antigens, through kinetic and quantitation assays. Limitations, for example in sensitivity and the availability of established assay formats, have restricted its adoption across other analytical applications. This article highlights three case studies which demonstrate the expansion of BLI into novel applications, spanning the areas of protein detection and viral vector characterization. The first case study details the use of a multi-step signal amplification assay to enable the detection of low abundant molecules, such as cytokines, at lower concentrations than can be detected using the standard one-step binding approach. Cytokines are sandwiched between biotinylated and HRP-conjugated antibodies, then dipped into 3-amino-9-ethylcarbazole (AEC) reagent, resulting in an enhancement of the cytokine detection sensitivity. The second case study uses BLI for the quantitation of mixed populations of a bispecific antibody (bsAb). Bridging and dual binding assay formats are evaluated for their assessment of bsAb antigen binding kinetics and ability to determine the ratio of correctly assembled bsAb within a sample. In the third case study, BLI detection principles are used to estimate the percentage full capsids in a mixed population of AAV particles. Collectively, these case studies demonstrate the versatility of Octet® BLI and highlight its potential to support an increasing range of analytical workflows beyond its traditional applications. Full article
(This article belongs to the Special Issue Novel Optical Fiber Sensors for Biochemical and Biological Applications)
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15 pages, 3189 KB  
Article
Label-Free Microfluidic Modulation Spectroscopy Monitors RNA Origami Structure and Stability
by Phoebe S. Tsoi, Lathan Lucas, Allan Chris M. Ferreon, Ewan K. S. McRae and Josephine C. Ferreon
Biosensors 2026, 16(3), 166; https://doi.org/10.3390/bios16030166 - 16 Mar 2026
Viewed by 855
Abstract
RNA origami enables genetically encoded, single-stranded RNA nanostructures that can self-assemble through co-transcriptional folding and are increasingly deployed as scaffolds for biosensing, synthetic biology, and nanomedicine. A recurring practical bottleneck is scalable, solution-phase readout of whether a designed scaffold has reached its intended [...] Read more.
RNA origami enables genetically encoded, single-stranded RNA nanostructures that can self-assemble through co-transcriptional folding and are increasingly deployed as scaffolds for biosensing, synthetic biology, and nanomedicine. A recurring practical bottleneck is scalable, solution-phase readout of whether a designed scaffold has reached its intended base-paired architecture, whether it undergoes slow maturation or kinetic trapping, and how its stability is distributed across motifs. Here, we adapt microfluidic modulation spectroscopy (MMS) as a label-free structural biosensor for RNA folding by exploiting the rich 1760–1600 cm−1 vibrational fingerprints of RNA bases and base pairs. MMS alternates between sample and composition-matched buffer measurements in a microfluidic transmission cell to automatically subtract the solvent background, enabling high-quality spectral measurement from microliter volumes under native solution conditions. Using a six-helix-bundle-with-clasp (6HBC) RNA origami as a model, we established an analysis workflow (baselined second derivative and constrained deconvolution) to quantify paired versus unpaired populations. Thermal ramping resolves multiple unfolding events and yields an unfolding barcode that differs between young and mature ensembles. Importantly, MMS tracks post-transcriptional maturation from a kinetically trapped young conformer toward a more compact, base-paired mature state, consistent with prior cryo-EM/SAXS observations for 6HBC RNA origami. Together, these results position MMS as a rapid, automated, and scalable complement to high-resolution structure determination for engineering dynamic RNA origami biosensors. Full article
(This article belongs to the Special Issue Novel Optical Fiber Sensors for Biochemical and Biological Applications)
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