Immunoassays and Immunosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 28 February 2027 | Viewed by 292

Editor


E-Mail Website
Guest Editor
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China
Interests: biosensors; redox cycling; immunosensors; DNA sensors; aptasensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Immunosensors and immunoassays based on the specific antigen–antibody recognition are biosensing technologies that convert immune responses into detectable electrical and optical signals with transducers. They can primarily be divided into labeled and unlabeled types, such as enzyme-linked immunosorbent assays and lateral flow immunoassays. Its core components include antibody/antigen recognition elements and signal conversion devices. Immunosensors and immunoassays have evolved into general technologies for detecting different antigens/analytes with high-affinity antibodies for molecular recognition and appropriate labels for signal amplification. Recent studies have focused on developing innovative and efficient nanomaterials, artificial enzyme mimics, and nucleic acid labels to modulate the performances in a controlled and predictable manner to meet specific requirements. This Special Issue compiles novel research and review papers on advanced immunosensors and immunoassays. Signal amplification methods include metal nanoparticles, carbon nanomaterials, semiconductor nanoparticles, metal oxide nanostructures, natural enzymes, artificial enzyme mimics, nucleic acids, etc. Transduction elements encompass electrochemical, optical, pressure, temperature, mass change, and other methods. We warmly welcome multimodal platforms with different signals for simultaneous detection of multiple biomarkers and machine learning-assisted methods to improve diagnosis accuracy. 

Prof. Dr. Ning Xia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunosensors
  • immunoassays
  • multimodal platforms
  • machine learning
  • signal amplification
  • nanomaterials
  • artificial enzyme mimics
  • nucleic acid-based amplification

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

45 pages, 5320 KB  
Review
Overview in Electrochemical and Electrical Biosensors for Determining Blood Protein Biomarkers of Alzheimer’s Disease
by Fengli Gao, Lin Liu, Junyue Li, Shaoyang Chen and Xinyao Yi
Biosensors 2026, 16(8), 426; https://doi.org/10.3390/bios16080426 - 6 Aug 2026
Viewed by 182
Abstract
Early diagnosis of Alzheimer’s disease (AD) can facilitate the establishment and implementation of therapeutic interventions. The currently used diagnosis methods for AD mainly include cerebrospinal fluid analysis and positron emission tomography imaging. Due to their high invasiveness, high cost, and limited accessibility, these [...] Read more.
Early diagnosis of Alzheimer’s disease (AD) can facilitate the establishment and implementation of therapeutic interventions. The currently used diagnosis methods for AD mainly include cerebrospinal fluid analysis and positron emission tomography imaging. Due to their high invasiveness, high cost, and limited accessibility, these technologies are difficult to meet the needs of large-scale population screening, grading diagnosis, and treatment, thereby limiting the popularization of early diagnosis of AD. The detection of blood biomarkers has become an important breakthrough in early screening and diagnosis of different diseases due to its non-invasive, low-cost, and easy-to-operation advantages. Recently, blood proteins such as amyloid-beta (Aβ), total and phosphorylated Tau, light chain neurofilaments (NFL), and glial fibrillary acidic protein (GFAP) have been considered promising biomarkers for the diagnosis of AD. However, there is currently no effective, minimally invasive, and easily accessible detection method for clinical diagnosis and risk prediction of AD. Electrochemical and electrical biosensors are highly sensitive, simple, fast, and cost-effective analytical tools for disease monitoring, drug development, and target detection. In this work, we comprehensively and systematically overview the progress of various electrochemical and electrical techniques for determining AD-related blood protein biomarkers, mainly including electrochemistry, electrochemiluminescence, photoelectrochemistry, quartz crystal microbalance, field-effect transistor, and organic electrochemical transistor. This work can provide guidance for researchers to develop novel electrochemical and electrical biosensors for early and accurate diagnosis of AD. Full article
(This article belongs to the Special Issue Immunoassays and Immunosensors)
Show Figures

Figure 1

Back to TopTop