Advanced Hybrid Materials and Innovative Transduction Mechanisms for Next-Generation Biosensing Platforms

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 1515

Special Issue Editor


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Guest Editor
Department of Health and Biomedical Sciences, The University of Texas Rio Grande Valley, Brownsville, TX 78520, USA
Interests: conductive polymers; biosensors; bioelectronics; tissue regeneration; cancer
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Special Issue Information

Dear Colleagues,

The rapid evolution of biosensing technologies is driven by innovative materials and transduction mechanisms that enable sensitive, selective, and real-time detection of biological and chemical analytes. Conductive polymers remain a cornerstone of this field due to their excellent electrical conductivity, biocompatibility, tunable properties, and ease of integration into hybrid systems. However, the integration of diverse advanced materials—such as nanomaterials, hybrid composites, and biomimetic structures—with a wide array of sensing mechanisms (including electrochemical, optical, photonic, field-effect, mechanical, and piezoelectric) is expanding the capabilities of biosensors toward more robust, multifunctional platforms.

This Special Issue aims to showcase cutting-edge research and comprehensive reviews on advanced hybrid materials in biosensors, with a particular emphasis on conductive polymer-based systems while encompassing broader material innovations and integrated device platforms. Contributions are invited on novel material designs, signal transduction strategies, device fabrication, and/or practical implementations that address key challenges in sensitivity, stability, scalability, device integration, and pathways to commercialization.

We welcome multidisciplinary submissions exploring real-world applications, including point-of-care health diagnostics, wearable and implantable devices, environmental monitoring, food safety and quality control, and personalized medicine. Works that bridge materials science, bioengineering, nanotechnology, and application-focused development are especially encouraged, as they pave the way for next-generation biosensors that meet global health, sustainability, and safety needs.

Example Topics of Interest

  • Synthesis and functionalization of conductive polymers and their hybrids with nanomaterials (e.g., graphene, carbon nanotubes, and metal nanoparticles);
  • Organic electrochemical transistors (OECTs) and field–effect transistor-based biosensing platforms;
  • Electrochemical, optical, photonic, surface plasmon resonance (SPR), and piezoelectric transduction mechanisms;
  • Integration of CMOS-compatible sensors, flexible electronics, and microfluidic systems;
  • Wearable, implantable, and point-of-care biosensing devices;
  • Biosensors for biomarker detection in health diagnostics and personalized medicine;
  • Applications in environmental monitoring, pollutant detection, and food safety analysis;
  • Strategies for improving selectivity, stability, reproducibility, and miniaturization;
  • Signal amplification techniques, multimodality sensing, and data integration;
  • Challenges and advances in scalability, manufacturing, and commercialization of biosensing technologies.

Dr. Abijeet S. Mehta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • conductive polymers
  • organic electrochemical transistors (OECTs)
  • CMOS-based image sensors
  • piezoelectric biosensors
  • surface plasmon resonance (SPR) sensors
  • hybrid biosensors
  • biomedical diagnostics

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Published Papers (1 paper)

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Research

14 pages, 3044 KB  
Article
Liquid-Gated Field-Effect Transistor-Based Biosensor for Uric Acid Detection
by Rafiq Ahmad, Abdullah, Altaf Khan, Fohad Mabood Husain and Byeong-Il Lee
Biosensors 2026, 16(3), 142; https://doi.org/10.3390/bios16030142 - 1 Mar 2026
Viewed by 746
Abstract
Monitoring uric acid (UA) concentration is crucial for human health, enabling early detection and prevention of metabolic disorders as well as assessing renal function and overall metabolic balance. Herein, we developed a field-effect transistor (FET)-based UA biosensor using hydrothermally synthesized vertical zinc oxide [...] Read more.
Monitoring uric acid (UA) concentration is crucial for human health, enabling early detection and prevention of metabolic disorders as well as assessing renal function and overall metabolic balance. Herein, we developed a field-effect transistor (FET)-based UA biosensor using hydrothermally synthesized vertical zinc oxide (ZnO) nanorods (NRs) and uricase. The fabricated FET biosensor was tested in phosphate-buffered saline (PBS) at increasing UA concentrations to evaluate its biosensing performance. The FET biosensor yields a sensitivity of 12.45 μA·mM−1·cm−2, covering a dynamic range of 0.05–2.75 mM. The calculated detection limit was ~0.0043 mM. The improved sensing performance results in a substantial enhancement of both detection sensitivity and limit of detection compared to the traditional lateral electrode setup. Additionally, selectivity, storage stability, fabrication reproducibility, and applicability for serum UA detection were evaluated. Overall, the vertical electrode configuration of the UA biosensor has the potential to be further extended for the sensitive detection of additional biomarkers. Full article
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