Topical Collection "Feature Papers in 'Biological and Bio- Materials' Section"

A topical collection in Biomolecules (ISSN 2218-273X). This collection belongs to the section "Biological and Bio- Materials".

Editor

Dr. Bahman Anvari
E-Mail Website
Collection Editor
Department of Bioengineering, University of California Riverside, Riverside, CA 92521, USA
Interests: bioinspired materials; photonic materials; photomedicine; optical imaging; nanomedicine and nanobiotechnology; delivery systems; cell membrane mechanics
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

This Topical Collection, "Feature Papers in 'Biological and Bio- Materials' Section", aims to collect high-quality research articles, review articles, and communications on all aspects of biological and bio- materials. It is dedicated to recent advances in the research area of biological and bio- materials, and comprises a selection of exclusive papers from the Editorial Board Members (EBMs) of the 'Biological and Bio- Materials' Section, as well as invited papers from relevant experts. We also welcome established experts in the field to make contributions to this Topical Collection. Please note that all invited papers will be published online once accepted. We aim to represent our Section as an attractive open access publishing platform for biological and bio- materials research.

We invite submissions focusing on, but not restricted to:
  • Molecular diagnostics, therapeutics, and theranostics.
  • Biologically inspired materials and constructs.
  • Biomimetics.
  • Stem cells.
  • Regenerative medicine.
  • Self-assembling materials.
  • Design, synthesis, and characterization of engineered materials.
  • Delivery systems.
  • Immunogenicity and toxicity.
  • Smart, responsive, and bioactive materials.

Dr. Bahman Anvari
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

2022

Article
The Acute and Short-Term Inhalation of Carbon Nanofiber in Sprague-Dawley Rats
Biomolecules 2022, 12(10), 1351; https://doi.org/10.3390/biom12101351 - 22 Sep 2022
Viewed by 331
Abstract
The inhalation toxicity of carbon nanofibers (CNFs) is not clearly known due to relatively few related studies reported. An acute inhalation study and short-term inhalation study (5 days) were therefore conducted using Sprague-Dawley rats. In the acute inhalation study, the rats were grouped [...] Read more.
The inhalation toxicity of carbon nanofibers (CNFs) is not clearly known due to relatively few related studies reported. An acute inhalation study and short-term inhalation study (5 days) were therefore conducted using Sprague-Dawley rats. In the acute inhalation study, the rats were grouped and exposed to a fresh air control or to low (0.238 ± 0.197), moderate (1.935 ± 0.159), or high (24.696 ± 6.336 mg/m3) CNF concentrations for 6 h and thereafter sacrificed at 14 days. For the short-term inhalation study, the rats were grouped and exposed to a fresh air control or low (0.593 ± 0.019), moderate (2.487 ± 0.213), or high (10.345 ± 0.541 mg/m3) CNF concentrations for 6 h/day for 5 days and sacrificed at 1, 3, and 21 days post-exposure. No mortality was observed in the acute inhalation study. Thus, the CNF LC50 was higher than 25 mg/m3. No significant body or organ weight changes were noted during the 5 days short-term inhalation study or during the post-exposure period. No significant effects of toxicological importance were observed in the hematological, blood biochemical, and coagulation tests. In addition, the bronchoalveolar lavage (BAL) fluid cell differential counts and BAL inflammatory markers showed no CNF-exposure-relevant changes. The histopathological examination also found no CNF-exposure-relevant histopathological lesions. Thus, neither acute nor 5 days inhalation exposure to CNFs induced any noticeable toxicological responses. Full article
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Figure 1

Article
“Fingerprinting” Benign and Cancerous Skin Lesions Using Vibrational Optical Coherence Tomography: Differentiation among Cancerous Lesion Types Based on the Presence of New Cells, Blood Vessels, and Fibrosis
Biomolecules 2022, 12(10), 1332; https://doi.org/10.3390/biom12101332 - 21 Sep 2022
Viewed by 218
Abstract
In this study, we use vibrational optical coherence tomography (VOCT) to examine the morphology and stiffness of benign and cancerous lesions. Lesion images and 3D plots of weighted displacement versus frequency and depth were used to compare the cellular, dermal collagen, new blood [...] Read more.
In this study, we use vibrational optical coherence tomography (VOCT) to examine the morphology and stiffness of benign and cancerous lesions. Lesion images and 3D plots of weighted displacement versus frequency and depth were used to compare the cellular, dermal collagen, new blood vessels, and fibrotic composition of normal skin, actinic keratoses (AK), nodular and superficial basal cell carcinomas (BCCs), squamous cell carcinomas (SCCs), and melanomas. The results of this study suggest that benign and cancerous lesions differ based on the addition of new cells with increased resonant frequency and stiffness (80 Hz, 1.8 MPa), new blood vessel peaks (130 Hz, 4.10 MPa) that appear to be less stiff than normal blood vessels, and new fibrous tissue peaks (260 Hz, 15–17 MPa) that are present in carcinomas but not in normal skin and only partially present (80 Hz and 130 Hz only) in AKs. Results obtained by creating images based on the location of the 80 Hz, 130 Hz, and 260 Hz peaks of cancerous skin lesions suggest that the fibrous tissue appears to surround the new cells and new lesion blood vessels. The results of this study suggest that the morphology and location of the fibrous tissues in relation to the new cancer-associated cells and lesion blood vessels may provide information on the invasiveness and metastatic potential of skin cancers. The invasiveness and metastatic potential of melanomas may be a result of the cancer-associated cells laying down fibrous tissue that is used as a pathway for migration. The new cancer-associated blood vessels in the vicinity of the new cancer-associated cells may promote this migration and eventual metastasis. The ratios of peak heights 50/130 Hz and 80/130 Hz of normal cells, new lesion cells, new lesion blood vessels, and fibrotic tissue may be used as a “fingerprint” for detecting melanoma and to differentiate it from other skin cancers non-invasively using VOCT. Full article
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Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: “Fingerprinting” Benign and Cancerous Skin Lesions Using Vibrational Optical Coherence Tomography: Differentiation Among Cancerous Lesion Types Based on the New Cellular, New Blood Vessel and Fibrotic Peak Ratios
Authors: Frederick H Silver; Tanmay Deshmukh; Nicole Ryan; Ariella Romm; Hari Nadiminti
Affiliation: Rutgers, The State University of New Jersey

Title: To be determined
Authors: Nathan Gallant; et al
Affiliation: Department of Mechanical Engineering , University of South Florida

Title: To be determined
Authors: Wei Seong Toh; et al
Affiliation: Faculty of Dentistry, National University of Singapore

Title: To be determined
Authors: Shinji Sakai; et al
Affiliation: Department of Materials Science and Engineering Osaka University, Japan

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