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Article

The Acute and Short-Term Inhalation of Carbon Nanofiber in Sprague-Dawley Rats

1
HCT Co. Ltd., Icheon 17383, Korea
2
Institute of Health and Environment, Seoul National University, Seoul 08826, Korea
3
College of Medicine, Chung-Ang University, Seoul 06974, Korea
4
Occupational Lung Diseases Research Institute, KCOMWEL, Incheon 21417, Korea
5
Department of Mechanical Engineering, Hanyang University, Ansan 15586, Korea
6
Haematology and Molecular Medicine, University of the Witwatersrand, Private Bag 3, Johannesburg 2050, South Africa
7
Water Research Group, Unit for Environmental Sciences and Management, North University, Private Bag X6001, Potchefstroom 2520, South Africa
*
Author to whom correspondence should be addressed.
Academic Editors: Bahman Anvari and Deng-Guang Yu
Biomolecules 2022, 12(10), 1351; https://doi.org/10.3390/biom12101351
Received: 20 July 2022 / Revised: 16 September 2022 / Accepted: 16 September 2022 / Published: 22 September 2022
(This article belongs to the Collection Feature Papers in 'Biological and Bio- Materials' Section)
The inhalation toxicity of carbon nanofibers (CNFs) is not clearly known due to relatively few related studies reported. An acute inhalation study and short-term inhalation study (5 days) were therefore conducted using Sprague-Dawley rats. In the acute inhalation study, the rats were grouped and exposed to a fresh air control or to low (0.238 ± 0.197), moderate (1.935 ± 0.159), or high (24.696 ± 6.336 mg/m3) CNF concentrations for 6 h and thereafter sacrificed at 14 days. For the short-term inhalation study, the rats were grouped and exposed to a fresh air control or low (0.593 ± 0.019), moderate (2.487 ± 0.213), or high (10.345 ± 0.541 mg/m3) CNF concentrations for 6 h/day for 5 days and sacrificed at 1, 3, and 21 days post-exposure. No mortality was observed in the acute inhalation study. Thus, the CNF LC50 was higher than 25 mg/m3. No significant body or organ weight changes were noted during the 5 days short-term inhalation study or during the post-exposure period. No significant effects of toxicological importance were observed in the hematological, blood biochemical, and coagulation tests. In addition, the bronchoalveolar lavage (BAL) fluid cell differential counts and BAL inflammatory markers showed no CNF-exposure-relevant changes. The histopathological examination also found no CNF-exposure-relevant histopathological lesions. Thus, neither acute nor 5 days inhalation exposure to CNFs induced any noticeable toxicological responses. View Full-Text
Keywords: carbon nanofiber; inhalation toxicity; acute; short-term inhalation study (STIS) carbon nanofiber; inhalation toxicity; acute; short-term inhalation study (STIS)
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MDPI and ACS Style

Jo, M.S.; Kim, B.W.; Kim, Y.H.; Kim, J.K.; Kim, H.P.; Shin, J.H.; Lee, G.H.; Ahn, K.; Gulumian, M.; Yu, I.J. The Acute and Short-Term Inhalation of Carbon Nanofiber in Sprague-Dawley Rats. Biomolecules 2022, 12, 1351. https://doi.org/10.3390/biom12101351

AMA Style

Jo MS, Kim BW, Kim YH, Kim JK, Kim HP, Shin JH, Lee GH, Ahn K, Gulumian M, Yu IJ. The Acute and Short-Term Inhalation of Carbon Nanofiber in Sprague-Dawley Rats. Biomolecules. 2022; 12(10):1351. https://doi.org/10.3390/biom12101351

Chicago/Turabian Style

Jo, Mi Seong, Boo Wook Kim, Young Hun Kim, Jin Kwon Kim, Hoi Pin Kim, Jae Hoon Shin, Gun Ho Lee, Kangho Ahn, Mary Gulumian, and Il Je Yu. 2022. "The Acute and Short-Term Inhalation of Carbon Nanofiber in Sprague-Dawley Rats" Biomolecules 12, no. 10: 1351. https://doi.org/10.3390/biom12101351

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