Updates on Mitochondria and Cancer
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: 15 January 2026 | Viewed by 920
Special Issue Editors
Interests: mitochondrial homeostasis (biogenesis, mitophagy and dynamics); mtDNA alterations; mitochondrial dysfunction in cancer; mitochondrial therapeutic targets in cancer
Special Issues, Collections and Topics in MDPI journals
Interests: mitochondrial proteome in ageing, muscle unloading and cancer; mitochondrial biogenesis; mitochondrial antioxidant proteins; mitochondrial DNA-binding proteins; mitochondrial dynamics; metabolomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria play a key role in cancer, and their involvement is not limited to ATP production. Mitochondria also produce reactive oxygen species and building blocks to support rapid cell proliferation; therefore, the deregulation of mitochondrial function is associated with the development and progression of cancer.
Metabolic reprogramming in cancer cells occurs through the modulation of mitochondrial metabolic pathways and changes in mitochondrial homeostasis (biogenesis, mitophagy, dynamics, redox balance, and protein homeostasis). A deeper understanding of altered mitochondrial pathways in cancer may provide new opportunities to identify potential therapeutic targets. In addition, several studies have shown that mitochondria are also involved in cancer drug resistance. Finally, the analysis of mitochondrial markers in cancer tissues and body fluids may provide a tool for early cancer diagnosis and the monitoring of disease progression.
Thus, this Special Issue will focus on altered mitochondrial pathways in cancer, new strategies/compounds that may induce cancer cell death by altering mitochondrial function, mitochondria and cancer drug resistance, and mitochondrial markers as new diagnostic/prognostic tools. We invite authors to submit original research and review articles related to any of these aspects.
Dr. Antonella Cormio
Dr. Clara Musicco
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mitochondrial dysfunction in cancer
- mitochondrial metabolomics
- mitochondria and cancer therapy
- mitochondria and cancer drug resistance
- prognostic/predictive mitochondrial markers in cancer tissues and body fluids
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