Special Issue "Functions of Nicotinamide N-Methyltransferase in Cancer"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Enzymology".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editor

Dr. Davide Sartini
E-Mail Website
Guest Editor
Department of Clinical Sciences, Polytechnic University of Marche, via Tronto 10/a, 60126 Ancona, Italy
Interests: biochemistry; molecular biology; medicinal chemistry; cell biology; molecular oncology; tumor biomarker discovery

Special Issue Information

Dear Colleagues,

A Special Issue on the “Functions of Nicotinamide N-Methyltransferase in Cancer” is being prepared for the journal Biomolecules.

Human nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the N-methylation of nicotinamide, pyridines, and other structural analogues, using S-adenosyl-L-methionine as the methyl donor. NNMT plays a fundamental role in nicotinamide catabolism, as well as in the biotransformation and detoxification of many xenobiotics, as it belongs to the group of phase II metabolizing enzymes. NNMT is mainly expressed in the liver, and its upregulation has been found in a wide variety of solid cancers, including papillary thyroid carcinoma, colorectal cancer, gastric cancer, lung cancer, renal cell carcinoma, bladder cancer, oral carcinoma, and melanoma. However, the significance of NNMT overexpression in cancer cells, as well as the cellular effects exerted by this dysregulation, have not been totally elucidated. Collectively, the data reported to date seem to demonstrate that NNMT could be involved in cell proliferation, viability, and migration; metastatic potential; as well as tumor cell sensitivity to chemotherapeutic treatment. Moreover, these results suggest an interesting role played by NNMT as a potential diagnostic and/or prognostic biomarker, supporting the hypothesis that it could represent a promising molecular target for effective anticancer therapy.

Dr. Davide Sartini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nicotinamide N-methyltransferase
  • S-adenosyl-L-methionine
  • nicotinamide
  • diagnostic and prognostic marker
  • molecular target
  • targeted therapy
  • cancer cell phenotype

Published Papers

This special issue is now open for submission.
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