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Review

Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts

1
Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France
2
CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(3), 391; https://doi.org/10.3390/biom10030391
Received: 29 January 2020 / Revised: 26 February 2020 / Accepted: 29 February 2020 / Published: 3 March 2020
Parkinson’s Disease (PD) is characterized both by the loss of dopaminergic neurons in the substantia nigra and the presence of cytoplasmic inclusions called Lewy Bodies. These Lewy Bodies contain the aggregated α-synuclein (α-syn) protein, which has been shown to be able to propagate from cell to cell and throughout different regions in the brain. Due to its central role in the pathology and the lack of a curative treatment for PD, an increasing number of studies have aimed at targeting this protein for therapeutics. Here, we reviewed and discussed the many different approaches that have been studied to inhibit α-syn accumulation via direct and indirect targeting. These analyses have led to the generation of multiple clinical trials that are either completed or currently active. These clinical trials and the current preclinical studies must still face obstacles ahead, but give hope of finding a therapy for PD with time. View Full-Text
Keywords: Parkinson’s disease; α-synuclein; neurodegeneration; therapy; aggregation Parkinson’s disease; α-synuclein; neurodegeneration; therapy; aggregation
MDPI and ACS Style

Teil, M.; Arotcarena, M.-L.; Faggiani, E.; Laferriere, F.; Bezard, E.; Dehay, B. Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts. Biomolecules 2020, 10, 391. https://doi.org/10.3390/biom10030391

AMA Style

Teil M, Arotcarena M-L, Faggiani E, Laferriere F, Bezard E, Dehay B. Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts. Biomolecules. 2020; 10(3):391. https://doi.org/10.3390/biom10030391

Chicago/Turabian Style

Teil, Margaux, Marie-Laure Arotcarena, Emilie Faggiani, Florent Laferriere, Erwan Bezard, and Benjamin Dehay. 2020. "Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts" Biomolecules 10, no. 3: 391. https://doi.org/10.3390/biom10030391

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