Kinases Signaling in Cancers

Dear Colleagues,

Protein kinases are a large array of proteins which surveil signaling pathways and orchestrate fundamental physiological processes and cellular functions, such as development, hormone response and inflammation. They include: mitogen-activated protein kinases (MAPKs), triggered following stimulation at the cell surface of the tyrosine kinase receptors and G-coupled protein receptors; cyclin-dependent kinases (CDK), which respond to cyclins signaling; lipid kinases on plasma or organelle membranes (e.g. phosphoinositide 3-kinase, PI3K); autophagy-activated kinases (Unc-51, such as autophagy-activating kinase, ULK1/2), and Janus kinase–signal transducer and activator of transcription (JAK-STAT), which are a family of nonreceptor tyrosine kinases responding to intracellular cytokines. Their intracellular activity is regulated by different modulators (e.g., hormones, growth factors, cytokines and transition metals) which direct cells to their ultimate fate.

Upon dysregulation of their function, they are engaged in cancer initiation and progression and also in the acquisition of drug resistance. Thus, kinases have been the subject of intense research to unveil the underlying mechanisms and also as drug targets for cancer, particularly focusing on the identification of inhibitors to be used for clinical use.

This Special Issue aims to collect the most recent work in this field, in order to prompt further research, to pinpoint novel mechanisms underlying kinases involvement in cancer, and to suggest possible kinase-targeted drugs applicable in therapy.

Dr. Anastasia De Luca
Dr. Luisa Rossi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.