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Biomolecules
Special Issues
Connecting the Bone with Other Organs: A Reciprocal Cross-Talk
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Connecting the Bone with Other Organs: A Reciprocal Cross-Talk

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (15 March 2020) | Viewed by 19201

Special Issue Editors

Dr. Nadia Rucci

E-Mail Website
Guest Editor
Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Interests: bone; osteopetrosis; osteoporosis; bone metastases
Special Issues, Collections and Topics in MDPI journals
Dr. Bram van der Eerden

E-Mail Website
Guest Editor
Erasmus University Medical Center, Rotterdam, The Netherlands
Interests: bone metabolism; fracture healing; regeneration; calcium and phosphate homeostasis

Special Issue Information

Dear Colleagues,

The portrayal of the bone as a hard tissue has become obsolete following the discovery that it not only attends to classical locomotory, protection, and mineral homeostasis functions but also covers new unexpected roles. Indeed, the bone is a source of endocrine signals, through which it regulates several functions of our body, including energy metabolism, cognitive functions, male fertility, as well as organs like muscles and kidneys. Likewise, the bone receives regulatory signals from other organs. It follows that the bone actively communicates with other organs and participates in whole body homeostasis, in ways that are still in part unknown. Therefore, understanding the mechanisms involved in the bidirectional cross-talk that exists between the bone and other organs is mandatory to guarantee the health of the entire body.

Prof. Nadia Rucci
Dr. Bram van der Eerden
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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30 pages, 3849 KiB  
Review
Interactions between Muscle and Bone—Where Physics Meets Biology
by Marietta Herrmann, Klaus Engelke, Regina Ebert, Sigrid Müller-Deubert, Maximilian Rudert, Fani Ziouti, Franziska Jundt, Dieter Felsenberg and Franz Jakob
Biomolecules 2020, 10(3), 432; https://doi.org/10.3390/biom10030432 - 10 Mar 2020
Cited by 84 | Viewed by 12834
Abstract
Muscle and bone interact via physical forces and secreted osteokines and myokines. Physical forces are generated through gravity, locomotion, exercise, and external devices. Cells sense mechanical strain via adhesion molecules and translate it into biochemical responses, modulating the basic mechanisms of cellular biology [...] Read more.
Muscle and bone interact via physical forces and secreted osteokines and myokines. Physical forces are generated through gravity, locomotion, exercise, and external devices. Cells sense mechanical strain via adhesion molecules and translate it into biochemical responses, modulating the basic mechanisms of cellular biology such as lineage commitment, tissue formation, and maturation. This may result in the initiation of bone formation, muscle hypertrophy, and the enhanced production of extracellular matrix constituents, adhesion molecules, and cytoskeletal elements. Bone and muscle mass, resistance to strain, and the stiffness of matrix, cells, and tissues are enhanced, influencing fracture resistance and muscle power. This propagates a dynamic and continuous reciprocity of physicochemical interaction. Secreted growth and differentiation factors are important effectors of mutual interaction. The acute effects of exercise induce the secretion of exosomes with cargo molecules that are capable of mediating the endocrine effects between muscle, bone, and the organism. Long-term changes induce adaptations of the respective tissue secretome that maintain adequate homeostatic conditions. Lessons from unloading, microgravity, and disuse teach us that gratuitous tissue is removed or reorganized while immobility and inflammation trigger muscle and bone marrow fatty infiltration and propagate degenerative diseases such as sarcopenia and osteoporosis. Ongoing research will certainly find new therapeutic targets for prevention and treatment. Full article
(This article belongs to the Special Issue Connecting the Bone with Other Organs: A Reciprocal Cross-Talk)
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20 pages, 963 KiB  
Review
Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment
by Jennifer Zarrer, Marie-Therese Haider, Daniel J. Smit and Hanna Taipaleenmäki
Biomolecules 2020, 10(2), 337; https://doi.org/10.3390/biom10020337 - 19 Feb 2020
Cited by 30 | Viewed by 5815
Abstract
Bone is the most common metastatic site in breast cancer. Upon arrival to the bone, disseminated tumor cells can undergo a period of dormancy but often eventually grow and hijack the bone microenvironment. The bone marrow microenvironment consists of multiple cell types including [...] Read more.
Bone is the most common metastatic site in breast cancer. Upon arrival to the bone, disseminated tumor cells can undergo a period of dormancy but often eventually grow and hijack the bone microenvironment. The bone marrow microenvironment consists of multiple cell types including the bone cells, adipocytes, endothelial cells, and nerve cells that all have crucial functions in the maintenance of bone homeostasis. Tumor cells severely disturb the tightly controlled cellular and molecular interactions in the bone marrow fueling their own survival and growth. While the role of bone resorbing osteoclasts in breast cancer bone metastases is well established, the function of other bone cells, as well as adipocytes, endothelial cells, and nerve cells is less understood. In this review, we discuss the composition of the physiological bone microenvironment and how the presence of tumor cells influences the microenvironment, creating a pathological crosstalk between the cells. A better understanding of the cellular and molecular events that occur in the metastatic bone microenvironment could facilitate the identification of novel cellular targets to treat this devastating disease. Full article
(This article belongs to the Special Issue Connecting the Bone with Other Organs: A Reciprocal Cross-Talk)
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