Next Article in Journal
Kinetic Study of the Biodegradation of Acephate by Indigenous Soil Bacterial Isolates in the Presence of Humic Acid and Metal Ions
Previous Article in Journal
Rings, Hexagons, Petals, and Dipolar Moment Sink-Sources: The Fanciful Behavior of Water around Cyclodextrin Complexes
Previous Article in Special Issue
Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment
Open AccessReview

Interactions between Muscle and Bone—Where Physics Meets Biology

1
Orthopedic Department, Bernhard-Heine-Center for Locomotion Research, IZKF Research Group Tissue regeneration in musculoskeletal diseases, University Hospital Würzburg, University of Wuerzburg, 97070 Würzburg, Germany
2
Department of Medicine 3, FAU University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany
3
Orthopedic Department, Bernhard-Heine-Center for Locomotion Research, University of Würzburg, IGZ, 97076 Würzburg, Germany
4
Orthopedic Department, Bernhard-Heine-Center for Locomotion Research, University of Würzburg, 97074 Würzburg, Germany
5
Department of Internal Medicine II, University Hospital Würzburg, 97080 Würzburg, Germany
6
Privatpraxis für Muskel- und Knochenkrankheiten, 12163 Berlin Germany
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(3), 432; https://doi.org/10.3390/biom10030432
Received: 8 January 2020 / Revised: 27 February 2020 / Accepted: 5 March 2020 / Published: 10 March 2020
(This article belongs to the Special Issue Connecting the Bone with Other Organs: A Reciprocal Cross-Talk)
Muscle and bone interact via physical forces and secreted osteokines and myokines. Physical forces are generated through gravity, locomotion, exercise, and external devices. Cells sense mechanical strain via adhesion molecules and translate it into biochemical responses, modulating the basic mechanisms of cellular biology such as lineage commitment, tissue formation, and maturation. This may result in the initiation of bone formation, muscle hypertrophy, and the enhanced production of extracellular matrix constituents, adhesion molecules, and cytoskeletal elements. Bone and muscle mass, resistance to strain, and the stiffness of matrix, cells, and tissues are enhanced, influencing fracture resistance and muscle power. This propagates a dynamic and continuous reciprocity of physicochemical interaction. Secreted growth and differentiation factors are important effectors of mutual interaction. The acute effects of exercise induce the secretion of exosomes with cargo molecules that are capable of mediating the endocrine effects between muscle, bone, and the organism. Long-term changes induce adaptations of the respective tissue secretome that maintain adequate homeostatic conditions. Lessons from unloading, microgravity, and disuse teach us that gratuitous tissue is removed or reorganized while immobility and inflammation trigger muscle and bone marrow fatty infiltration and propagate degenerative diseases such as sarcopenia and osteoporosis. Ongoing research will certainly find new therapeutic targets for prevention and treatment. View Full-Text
Keywords: muscle; bone; mechanosensing; mechanotransduction; myokines; osteokines adaptation muscle; bone; mechanosensing; mechanotransduction; myokines; osteokines adaptation
Show Figures

Figure 1

MDPI and ACS Style

Herrmann, M.; Engelke, K.; Ebert, R.; Müller-Deubert, S.; Rudert, M.; Ziouti, F.; Jundt, F.; Felsenberg, D.; Jakob, F. Interactions between Muscle and Bone—Where Physics Meets Biology. Biomolecules 2020, 10, 432. https://doi.org/10.3390/biom10030432

AMA Style

Herrmann M, Engelke K, Ebert R, Müller-Deubert S, Rudert M, Ziouti F, Jundt F, Felsenberg D, Jakob F. Interactions between Muscle and Bone—Where Physics Meets Biology. Biomolecules. 2020; 10(3):432. https://doi.org/10.3390/biom10030432

Chicago/Turabian Style

Herrmann, Marietta; Engelke, Klaus; Ebert, Regina; Müller-Deubert, Sigrid; Rudert, Maximilian; Ziouti, Fani; Jundt, Franziska; Felsenberg, Dieter; Jakob, Franz. 2020. "Interactions between Muscle and Bone—Where Physics Meets Biology" Biomolecules 10, no. 3: 432. https://doi.org/10.3390/biom10030432

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop