Role of EMT Transcription Factors in Hematopoietic Development, Immune Cell Function and Leukemic Transformation
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: closed (25 February 2024) | Viewed by 2584
Special Issue Editor
Interests: cancer biology; cell fate engineering; epigenetics; hematopoiesis; in vivo disease modeling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Transcription factors (TFs), such as ZEB (ZEB1/2), SNAI (SNAI1-3), and TWIST (TWIST1/2) members, are involved in the regulation of epithelial-to-mesenchymal cell transition (EMT) events associated with a loss of epithelial polarity during developmental processes such as gastrulation and neural crest delamination. From a pathological perspective, these EMT-associated transcription factors (EMT-TFs) can be co-opted to drive cancer cell metastasis and therapy resistance and relapse and enhance cancer stemness properties. These EMT-TFs are not only limited to regulating aspects of epithelial cell pathophysiology but have also been demonstrated to play essential cell-autonomous roles in regulating hematopoietic cell differentiation and immune cell function. Hematopoietic cell lineage mutation and/or dysregulated expression of these EMT-TFs can lead to hematological malignancies and have been implicated in acute myeloid and lymphoid leukemia initiation and progression. Alterations in EMT-TF function are associated with alterations in key epigenetic regulator activity and may represent potential targets for novel cancer therapies. This Special Issue aims to bring together recent primary data articles as well as reviews highlighting advancements in our understanding of the roles that these EMT-TFs play in hematopoietic development, immune cell function, and leukemic transformation. Papers dealing with the role of EMT-TFs in immune cell surveillance and immune checkpoint control in cancer are also welcome.
Dr. Jody Jonathan Haigh
Guest Editor
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Keywords
- transcription factors
- epigenetics
- hematopoiesis
- leukemia
- immune cell function
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