Sex Differences in Biomedical Research
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (15 January 2024) | Viewed by 20875
Special Issue Editor
Interests: lipid metabolism; lipidomic; sex differences; sex hormones; nutrition; metabolic syndrome
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Until recently, instructions or guidance on the effect of sex on basic and preclinical research were rare. Based on recent human and animal research over the past decade, it is now widely accepted that both biological and physiological functions in health and disease are influenced by sex-based differences. Some effort has recently been made to better represent women in clinical trials and to accept sex as a biological variable in biomedical research. Sex has been recognized as an important basic human variable that should be considered when planning studies in biomedical and health-related research, but much effort must still be made. For example, premenopausal women seem to have a natural protection to various disorders, probably due to circulating estrogen, since this protection disappears after menopause. However, the mechanism by which circulating estrogen would protect females from metabolic dysfunctions is still largely unknown. Importantly, the existence of sex differences in health implies that one sex has a specific factor or process that protects from disease. If that factor can be modulated, either directly or by modifying its downstream pathways, then disease development and/or progression may be tempered. Every cell in our bodies has a sex, which means that women and men are also different at the cellular level. This implies that diseases, nutrients, pollutants, and treatments may impact women and men differently. Therefore, we cannot continue to ignore sex differences in biomedical research, and considering sex as a biological variable is fundamental to perform good and efficient science.
The purpose of this Special Issue is to introduce a sex-biased approach in biomedical research. To develop more effective diagnostic, treatment, and prevention strategies, it is crucial to elucidate the molecular and cellular mechanisms and the causes underlying sex-dependent biological response in human disease.
Dr. Marion Korach-André
Guest Editor
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Keywords
- sex differences
- metabolism
- obesity
- diet
- nutrition
- cancer
- metabolic syndrome
- type-2 diabetes
- inflammation
- liver steatosis
- appetite
- cytokines
- adipokines
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