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Biomolecules
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Biomolecules and Biomaterials for Tissue Engineering, 2nd Edition
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Biomolecules and Biomaterials for Tissue Engineering, 2nd Edition

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Bio-Engineered Materials".

Deadline for manuscript submissions: closed (21 May 2025) | Viewed by 2176

Special Issue Editor

Prof. Dr. Shinji Sakai

E-Mail Website
Guest Editor
Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Osaka 560-8531, Japan
Interests: tissue engineering; regenerative medicine; bioprinting; enzymatic hydrogelation; polysaccharide; hydrogel; drug delivery; cancer model
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is with great delight that I present this Special Issue: "Biomolecules and Biomaterials for Tissue Engineering". Tracing back to its roots in the 1990s, tissue engineering has proven transformative in fields such as regenerative medicine, drug testing, and disease modeling. At the heart of this evolution are biomolecules and biomaterials, complex components that direct cellular behavior and enable the fabrication of functional, biomimetic tissues.

This Special Issue underscores the need for a more profound understanding of biomolecules and biomaterials and their diverse roles within tissue engineering. Our focus is on the development of novel biomolecules and biomaterials; their applications, including bioprinting; and the innovative strategies involved in their modification. Research on these key topics will be complemented by studies featuring cutting-edge tools and techniques designed to facilitate such progress.

This Special Issue aims to offer deep insights into the significance of biomolecules and biomaterials, highlighting their role as critical catalysts driving progress in tissue engineering. We invite authors to submit original research or reviews that will enrich this vital discourse.

Prof. Dr. Shinji Sakai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • bioactive molecules
  • cellular function
  • proliferation

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Related Special Issue

Published Papers (2 papers)

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Research

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28 pages, 12694 KiB  
Article
Evaluation of Biocompatible Materials for Enhanced Mesenchymal Stem Cell Expansion: Collagen-Coated Alginate Microcarriers and PLGA Nanofibers
by Manuel Jaime-Rodríguez, María Luisa Del Prado-Audelo, Norma Angélica Sosa-Hernández, Dulce Patricia Anaya-Trejo, Luis Jesús Villarreal-Gómez, Ángel Humberto Cabrera-Ramírez, Jesus Augusto Ruiz-Aguirre, Israel Núñez-Tapia, Marek Puskar, Emily Marques dos Reis, Silvia Letasiova and Rocío Alejandra Chávez-Santoscoy
Biomolecules 2025, 15(3), 345; https://doi.org/10.3390/biom15030345 - 27 Feb 2025
Viewed by 1062
Abstract
Mesenchymal stem cells (MSCs) hold significant potential in regenerative medicine, tissue engineering, and cultivated meat production. However, large-scale MSC production is limited by their need for surface adherence during growth. This study evaluates two biocompatible materials—collagen-coated alginate microcarriers and polylactic-co-glycolic acid (PLGA) nanofibers—as [...] Read more.
Mesenchymal stem cells (MSCs) hold significant potential in regenerative medicine, tissue engineering, and cultivated meat production. However, large-scale MSC production is limited by their need for surface adherence during growth. This study evaluates two biocompatible materials—collagen-coated alginate microcarriers and polylactic-co-glycolic acid (PLGA) nanofibers—as novel growth substrates to enhance MSC proliferation. Physicochemical characterization confirmed successful collagen integration on both materials. In vitro, bone marrow-derived MSCs (bmMSCs) cultured on collagen-coated alginate microcarriers exhibited significantly enhanced growth compared to commercial microcarriers, while PLGA nanofibers supported bmMSC growth comparable to traditional growth surfaces. Scanning Electron Microscopy (SEM) revealed that bmMSCs adhered not only to the surface but also grew within the porous structure of the alginate microcarriers. Mycoplasma testing confirmed that the bmMSCs were free from contamination. Both materials were assessed for biocompatibility using ISO-10993 guidelines, demonstrating no skin or ocular irritation, supporting their potential for in situ applications in clinical and therapeutic settings. This study highlights the promise of collagen-coated alginate microcarriers and PLGA nanofibers for scalable MSC production, offering efficient, biocompatible alternatives to traditional growth surfaces in regenerative medicine and cultivated meat manufacturing. Future research should focus on optimizing these materials for larger-scale production and exploring specific applications in therapeutic and food sectors. Full article
(This article belongs to the Special Issue Biomolecules and Biomaterials for Tissue Engineering, 2nd Edition)
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Review

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24 pages, 3834 KiB  
Review
Application and Mechanism of Adipose Tissue-Derived Microvascular Fragments in Tissue Repair and Regeneration
by Yu Gao, Cheng Liang, Bingqian Yang, Li Liao and Xiaoxia Su
Biomolecules 2025, 15(3), 422; https://doi.org/10.3390/biom15030422 - 17 Mar 2025
Viewed by 579
Abstract
One of the long-standing challenges in the field of tissue repair and regeneration is the rapid establishment of local microvascular circulation and restoration of perfusion at the site of defects or injuries. Recently, adipose tissue-derived microvascular fragments (ad-MVFs) have attracted increasing attention from [...] Read more.
One of the long-standing challenges in the field of tissue repair and regeneration is the rapid establishment of local microvascular circulation and restoration of perfusion at the site of defects or injuries. Recently, adipose tissue-derived microvascular fragments (ad-MVFs) have attracted increasing attention from researchers. Adipose tissue is rich in blood vessels, and significant progress has been made in the extraction and preservation techniques for microvascular fragments within it. Ad-MVFs promote tissue and organ repair and regeneration through three main mechanisms. First, they accelerate rapid and efficient vascularization at the injury site, enabling early vessel perfusion. Second, the stem cell components within ad-MVFs provide a rich source of cells for tissue and organ regeneration. Third, they play a role in immune regulation, facilitating integration with host tissues after implantation. The application methods of ad-MVFs are diverse. They can be directly implanted or pre-cultivated, facilitating their combination with various scaffolds and broadening their application scope. These properties have led to the wide use of ad-MVFs in tissue engineering, with promising prospects. This review demonstrates that ad-MVFs can serve as a reliable and highly feasible unit for tissue regeneration. Full article
(This article belongs to the Special Issue Biomolecules and Biomaterials for Tissue Engineering, 2nd Edition)
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