Cancer Epigenetics, Post-Translational Modification, and Drug Discovery

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 303

Special Issue Editor

Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
Interests: multi-functional transcription factor nuclear factor κB (NF-κB); epigenetics; drug discovery; inflammation; cancer

Special Issue Information

Dear Colleagues,

This Special Issue aims to explore the intricate interplay between epigenetic regulation and molecular drivers in oncogenesis, with a particular focus on the role of multi-functional transcription factors such as NF-κB. NF-κB is a key orchestrator of inflammatory responses and oncogenic signaling, and it is intricately linked to epigenetic modifications that drive cancer progression and therapeutic resistance.

We invite contributions that delve into the complex networks connecting epigenetic reprogramming, chromatin remodeling, post-translational modification, and DNA methylation with the activation of NF-κB and other molecular pathways.

Submissions may include original research, comprehensive reviews, or perspectives.

Dr. Tao Lu
Guest Editor

Manuscript Submission Information

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Keywords

  • cancer
  • drug Discovery
  • epigenetics
  • inflammation
  • NF–κB

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Published Papers (1 paper)

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Review

24 pages, 1610 KiB  
Review
Lactylation: From Molecular Insights to Disease Relevance
by Yao Xu, Lu Zhang, Dong Shang and Hong Xiang
Biomolecules 2025, 15(6), 810; https://doi.org/10.3390/biom15060810 - 3 Jun 2025
Viewed by 185
Abstract
Lactylation, referring to the covalent coupling of the lactyl group with lysine residues, is a recently defined post-translational modification. It has been demonstrated that lactylation can alter protein transcription, thereby affecting the transmission of genetic information and ultimately exerting diverse effects on health [...] Read more.
Lactylation, referring to the covalent coupling of the lactyl group with lysine residues, is a recently defined post-translational modification. It has been demonstrated that lactylation can alter protein transcription, thereby affecting the transmission of genetic information and ultimately exerting diverse effects on health and diseases. Here, we review the existing literature and summarize the characteristics and mechanisms of lactylation on both histone and non-histone proteins. We hope to explore lactylation targets for different diseases, thus providing potential clues for new therapeutic strategies. Full article
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