Non-coding RNAs and Circular RNAs in Tumor Angiogenesis
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 3697
Special Issue Editor
Interests: RNA metabolism; circRNA, translation; molecular biology; angiogenesis; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are two types of non-coding RNAs that have been shown to play a role in tumor angiogenesis, the process by which new blood vessels form in tumors to support their growth and spread. LncRNAs are linear RNAs, while circRNAs are covalently closed, continuous RNA circles that do not have a defined 5' or 3' end; both are longer than 200 nucleotides. Even though they are often present in low copy numbers in cells, some are critical gene expression regulators. Both have been found to regulate various pathophysiological cellular processes, including tumor angiogenesis, by acting as epigenetic regulators, transcriptional and post-transcriptional regulators, molecular scaffolds, decoys, miRNA sponges, or even by encoding novel peptides, challenging their “non-coding” quality.
Although lncRNAs and circRNAs have emerged as important regulators of tumor angiogenesis, and their dysregulation is linked to the progression of various types of cancer, the full scale of the molecular mechanisms by which these “non-coding” RNAs regulate tumor angiogenesis is yet to be uncovered, providing novel therapeutic perspectives.
This Special Issue welcomes submissions of original research articles or review articles documenting novel implications of lncRNAs and circRNAs in tumor angiogenesis.
Dr. Éric Lacazette
Guest Editor
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Keywords
- lncRNA
- circRNA
- cancer
- tumor angiogenesis
- metastasis
- tumor microenvironment
- EMT
- cancer therapy
- cancer diagnosis
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