Pathophysiological Mechanisms of Leukocyte Activation and Recruitment
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 27721
Special Issue Editors
2. DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, 37075 Göttingen, Germany
Interests: neutrophil activation; M1 and M2 macrophages; exosomes; sterile inflammation; diabetes; cardiovascular diseases
Special Issue Information
Dear Colleagues,
Inflammation is the protective mechanism of the organism against injurious factors. The major event regulating inflammatory responses is the punctual and localized recruitment of leukocytes. Multiple cellular and regulatory mechanisms have been described playing a role during the multi-step cascade leading to leukocyte recruitment from the bloodstream to the site of inflammation. Deregulations of these molecular mechanisms, causing either an overactivation or a downregulation of leukocyte activation, generate an uncontrolled inflammatory response, a typical feature of multiple pathological conditions, such as, but not limited to, diabetes, arthritis, cancer, and cardiovascular diseases. The analysis of the molecular mechanisms regulating leukocyte activation has highlighted the pivotal role of multiple pathways (integrin activation, cytoskeletal remodeling, NET formations, etc.). In addition, the exploration of the interactions between leukocytes and the vessel wall endothelium has emphasized the importance of this critical interface. Direct cellular interactions and/or paracrine communications are fundamental for a proper leukocyte activation and regulated leukocyte recruitment.
In this Special Issue, we would like to highlight new direct and indirect players involved in the regulation of leukocyte recruitment in pathophysiological conditions and to present advanced approaches to modulate detrimental leukocyte behaviors associated with pathological processes.
I warmly welcome submissions, including original papers and reviews, on this widely discussed topic.
Dr. Giulia Germena
Dr. Anika Cappenberg
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- leukocyte recruitment
- integrins
- inflammation
- cytoskeletal remodeling
- endothelial cells
- macrophage polarization
- immunomodulation
- paracrine signals
- exosomes
- cell-cell interaction
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.