Pathophysiological Mechanisms of Leukocyte Activation and Recruitment

Dear Colleagues,

Inflammation is the protective mechanism of the organism against injurious factors. The major event regulating inflammatory responses is the punctual and localized recruitment of leukocytes. Multiple cellular and regulatory mechanisms have been described playing a role during the multi-step cascade leading to leukocyte recruitment from the bloodstream to the site of inflammation. Deregulations of these molecular mechanisms, causing either an overactivation or a downregulation of leukocyte activation, generate an uncontrolled inflammatory response, a typical feature of multiple pathological conditions, such as, but not limited to, diabetes, arthritis, cancer, and cardiovascular diseases. The analysis of the molecular mechanisms regulating leukocyte activation has highlighted the pivotal role of multiple pathways (integrin activation, cytoskeletal remodeling, NET formations, etc.). In addition, the exploration of the interactions between leukocytes and the vessel wall endothelium has emphasized the importance of this critical interface. Direct cellular interactions and/or paracrine communications are fundamental for a proper leukocyte activation and regulated leukocyte recruitment.

In this Special Issue, we would like to highlight new direct and indirect players involved in the regulation of leukocyte recruitment in pathophysiological conditions and to present advanced approaches to modulate detrimental leukocyte behaviors associated with pathological processes.

I warmly welcome submissions, including original papers and reviews, on this widely discussed topic.

Dr. Giulia Germena
Dr. Anika Cappenberg
Guest Editors

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