Biology and Pathophysiology of Bone
A Special Issue of Biology (ISSN 2079-7737) belonging to the section "Medical Biology".
Deadline for manuscript submissions: 30 June 2027 | Viewed by 586
Editor
Interests: tumor microenvironment; bone metastasis; osteoporosis; bone regeneration; MSC; osteochondral regeneration; biomechanics
Special Issue Information
Dear Colleagues,
Bone is a dynamic, homeostatic tissue that enables movement, protects internal organs, and serves as a reservoir for calcium and growth factors. In healthy (particularly young) individuals, bone mass is maintained through a tightly regulated balance between formation by osteoblasts and resorption by osteoclasts. This cellular interplay also involves osteocytes, bone‐lining cells, and endothelial cells. Osteoclasts—multinucleated cells of the monocyte/macrophage lineage—mediate bone resorption, while osteoblasts—derived from mesenchymal stromal cells—synthesize new bone matrix.
Beginning in the third decade of life, cancellous bone mass gradually declines, and this loss accelerates with age. An imbalance in favor of increased resorption arises, and metabolic disorders or chronic inflammation can further exacerbate bone degradation, leading to reduced bone strength and an elevated risk of fragility fractures. Such fractures not only increase mortality but also impose substantial costs on healthcare systems through acute treatment and long‐term care.
In this Special Issue, we explore the molecular mechanisms underpinning metabolic and inflammatory bone diseases, examine the signaling cascades and factors driving age‐related bone loss, and cover therapeutic strategies. Work elucidating human molecular mechanisms is especially welcome.
Dr. Vera Grotheer
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolic bone diseases
- osteoporosis
- bone inflammaging
- bone aging
- bone molecular biology
- osteoblasts
- osteoclasts
- lining cells
- translational therapeutic approaches
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
