Probiotics and Gut Microbiome-Prospects and Challenges

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Microbiology".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 2218

Special Issue Editor


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Guest Editor
1. The Edison Family Center for Genome Sciences and Systems Biology, Washington University, St. Louis, MO 63110, USA
2. Center for Gut Microbiome and Nutrition Research, Washington University, St. Louis, MO 63110, USA
Interests: gut microbial derived metabolites; gut microbiota, host and diet interaction

Special Issue Information

Dear Colleagues,

The human gut harbors a complex and dynamic microbial ecosystem, known as the gut microbiome, which plays a crucial role in maintaining host health. The gut microbiome is involved in various physiological processes, including digestion, nutrient absorption, immune modulation, and protection against pathogens. Dysbiosis in the composition and function of the gut microbiome, has been associated with numerous diseases, such as inflammatory bowel disease, obesity, diabetes, and neurological disorders. Probiotics have emerged as a promising approach to modulate the gut microbiome and promote host health. Recent advances in probiotic research have shed light on the diverse mechanisms by which probiotics exert their beneficial effects, including the production of antimicrobial compounds, the modulation of immune responses, and the regulation of gut barrier function. However, the development and application of probiotics also face significant challenges, such as the need for better characterization of beneficial mechanisms and probiotic strains, the optimization of probiotic formulations and delivery systems, and the establishment of appropriate regulatory frameworks. This Special Issue aims to provide a comprehensive overview of the current state of knowledge in the field of probiotics and the gut microbiome, highlighting the latest research findings, identifying key challenges and opportunities, and discussing future directions for the development of safe and effective probiotic interventions to promote human health. Understanding the complex interactions between probiotics and the gut microbiome is crucial for harnessing their potential in preventing and treating various diseases, and for developing personalized probiotic therapies tailored to individual needs.

We are pleased to invite you to contribute to the Special Issue “Probiotics and Gut Microbiome-Prospects and Challenges” in the Microbiology section of the Journal: Biology. This Special Issue aims to provide a comprehensive overview of the current state of knowledge in the field of probiotics and the gut microbiome, highlighting the latest research findings, identifying key challenges and opportunities, and discussing future directions for the development of safe and effective probiotic interventions to promote human health.

By covering a wide range of topics related to probiotics and the gut microbiome, including the development and characterization of novel probiotic strains, the mechanisms of action of probiotics, the potential applications of probiotics in preventing and treating various diseases, and the challenges associated with the formulation, delivery, and regulation of probiotic products, this Special Issue will provide a valuable resource for researchers, clinicians, and industry professionals working in the field.

Dr. Jiye Cheng
Guest Editor

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Keywords

  • probiotics
  • gut microbiome
  • microbiota
  • gut health
  • probiotic mechanisms
  • probiotic applications
  • probiotic challenges
  • probiotic formulation
  • probiotic delivery
  • microbiome-host interactions

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Published Papers (1 paper)

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Review

24 pages, 2530 KiB  
Review
The Gut Microbiota and Colorectal Cancer: Understanding the Link and Exploring Therapeutic Interventions
by Imen Zalila-Kolsi, Dhoha Dhieb, Hussam A. Osman and Hadjer Mekideche
Biology 2025, 14(3), 251; https://doi.org/10.3390/biology14030251 - 28 Feb 2025
Viewed by 1779
Abstract
CRC remains a significant public health challenge due to its high prevalence and mortality rates. Emerging evidence highlights the critical role of the gut microbiota in both the pathogenesis of CRC and the efficacy of treatment strategies, including chemotherapy and immunotherapy. Dysbiosis, characterized [...] Read more.
CRC remains a significant public health challenge due to its high prevalence and mortality rates. Emerging evidence highlights the critical role of the gut microbiota in both the pathogenesis of CRC and the efficacy of treatment strategies, including chemotherapy and immunotherapy. Dysbiosis, characterized by imbalances in microbial communities, has been implicated in CRC progression and therapeutic outcomes. This review examines the intricate relationship between gut microbiota composition and CRC, emphasizing the potential for microbial profiles to serve as biomarkers for early detection and prognosis. Various interventions, such as prebiotics, probiotics, postbiotics, fecal microbiota transplantation, and dietary modifications, aim to restore microbiota balance and shift dysbiosis toward eubiosis, thereby improving health outcomes. Additionally, the integration of microbial profiling into clinical practice could enhance diagnostic capabilities and personalize treatment strategies, advancing the field of oncology. The study of intratumoral microbiota offers new diagnostic and prognostic tools that, combined with artificial intelligence algorithms, could predict treatment responses and assess the risk of adverse effects. Given the growing understanding of the gut microbiome–cancer axis, developing microbiota-oriented strategies for CRC prevention and treatment holds promise for improving patient care and clinical outcomes. Full article
(This article belongs to the Special Issue Probiotics and Gut Microbiome-Prospects and Challenges)
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