Special Issue "Neutrophil Extracellular Traps in Disease and Immunity"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 30 April 2023 | Viewed by 87

Special Issue Editor

Dr. Blake Cochran
E-Mail Website
Guest Editor
School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Interests: immunology; cholesterol in the mechanisms of disease development and progression; neutrophils

Special Issue Information

Dear Colleagues,

Neutrophils are the most abundant circulating leukocyte. Whilst neutrophils were originally defined as a ‘professional phagocyte’, the discovery of neutrophil extracellular traps (NETs) and the characterization of NETosis as more than simply a form of ‘cellular suicide’ added a new level of complexity to the role that these cells play in disease and immunity.

Beyond their role in the direct killing of pathogens, NETs are pro-inflammatory and can act as a trigger to activate other immune cells, both those involved in innate and adaptive immunity, thereby leading to an inflammatory response. Unregulated NETosis has been linked to the pathogenesis of many diseases, including cardiovascular disease, sepsis, cancer, and several autoimmune conditions.

NETs contain a wide array of biologically active proteins that activate signaling pathways in many cell types, contributing both to disease progression and pathogenesis as well as the immunological role of NETs.

For this Special Issue, we encourage the submission of manuscripts on any aspect of NETs—from the biochemical pathways involved in their production and release from cells through to the important roles that NETs and NET-associated factors play in modulating disease and immunity.

Dr. Blake Cochran
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • NETs
  • NETosis
  • neutrophils
  • inflammation
  • autoimmunity
  • cardiovascular disease
  • cancer
  • arthritis

Published Papers

This special issue is now open for submission.
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