Special Issue "Neutrophil Extracellular Traps in Disease and Immunity"
Deadline for manuscript submissions: 30 April 2023 | Viewed by 87
Neutrophils are the most abundant circulating leukocyte. Whilst neutrophils were originally defined as a ‘professional phagocyte’, the discovery of neutrophil extracellular traps (NETs) and the characterization of NETosis as more than simply a form of ‘cellular suicide’ added a new level of complexity to the role that these cells play in disease and immunity.
Beyond their role in the direct killing of pathogens, NETs are pro-inflammatory and can act as a trigger to activate other immune cells, both those involved in innate and adaptive immunity, thereby leading to an inflammatory response. Unregulated NETosis has been linked to the pathogenesis of many diseases, including cardiovascular disease, sepsis, cancer, and several autoimmune conditions.
NETs contain a wide array of biologically active proteins that activate signaling pathways in many cell types, contributing both to disease progression and pathogenesis as well as the immunological role of NETs.
For this Special Issue, we encourage the submission of manuscripts on any aspect of NETs—from the biochemical pathways involved in their production and release from cells through to the important roles that NETs and NET-associated factors play in modulating disease and immunity.
Dr. Blake Cochran
Manuscript Submission Information
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- cardiovascular disease