Deciphering the Biological Activity of Natural Compounds: Metabolic Control and Health Repercussions

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Plant Science".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1267

Special Issue Editors


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Guest Editor
Cosmetics and Natural Products Research (CosNat) Center, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand
Interests: phytopharmaceuticals; phytopharmacology; pharmaceutical biology; phytochemistry

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Guest Editor
Department of Biochemistry, Hemvati Nandan Bahuguna Garhwal University, Srinagar Garhwal 246174, Uttarakhand, India
Interests: cancer biology; oxidative stress; plant based therapeutics

Special Issue Information

Dear Colleagues,

Plants act as a vast source of phytochemicals and innumerable valuable secondary metabolites, many of which offer numerous health benefits. The importance of these phytochemicals has significantly increased over the years, owing to their remarkable healing capabilities, which may help improve human health. Intrestingly plants encompasses a rich reservoir of novel chemical compounds and promising candidates for the development of pharmaceuticals. Over the past ten years, various analytical techniques have been applied to highlight the possibility of plants as a source for substances that have both functional and medicinal significance. At the same time, there's a growing demand for medicinal and natural substances that are safe, have multiple uses, and exhibit enhanced characteristics, which necessitates in-depth research into such valuable substances from natural origin. Plant-derived bioactives, used in traditional medicine are popular around the globe, and the scientific community is now focusing on the health repercussions of this traditional wisdom at metabolic level. Investigating the use of plant-derived bioactives to promote good health has been an effective strategy in the search for potential treatments. Studies have shown that plant-derived bioactives modulate numerous factors that are involved in various health issues, such as inflammation, skin aging, diabetes, obesity, heart disease, allergies, cancer, aging, and more. Hence metabolic control and health repercussions of such natural compounds must be properly addressed.

This Special Issue is dedicated to exploring plant-derived bioactives as potential modulators of such factors, as these functions are crucial for understanding the role of these substances in health. This edition will also focus on the investigating medicinal plants across various global areas, showcasing them as important providers of bioactive substances. We warmly extend our invitation to scholars globally to contribute both research and commentary pieces on the possible molecular pathways through which plant-derived bioactives can act as antioxidants, anticancer, antidiabetic, anti-inflammatory etc. agents and potentially exert a beneficial influence on various matabolic ailements.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following: the plant-derived bioactives that explores the underlying molecular mechanism behind the biological activities. This issue also welcomes articles based on in-silico studies and network pharmacology. Moreover preclinical and clinical, in-vitro and in-vivo studies of plant-derived bioactives will also be considered.

We look forward to receiving your contributions. 

Dr. Abhay Prakash Mishra
Dr. Manisha Nigam
Guest Editors

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Keywords

  • bioactive compounds
  • cytotoxic activity
  • pharmacology
  • enzyme inhibition
  • antioxidants
  • molecular mechanisms
  • anti-inflammatory activity
  • in vivo/vitro models
  • phytochemical analysis/evaluation

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Published Papers (1 paper)

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Research

25 pages, 14674 KiB  
Article
Eco-Friendly Silver Nanoparticles Synthesis Method Using Medicinal Plant Fungal Endophytes—Biological Activities and Molecular Docking Analyses
by Harish Chandra, Sagar Vishwakarma, Nilesh Makwana, Arun S. Kharat, Vijeta Chaudhry, Sumit Chand, Rajendra Prasad, Soban Prakash, Annapurna Katara, Archana Yadav, Manisha Nigam and Abhay Prakash Mishra
Biology 2025, 14(8), 950; https://doi.org/10.3390/biology14080950 - 28 Jul 2025
Viewed by 607
Abstract
The integration of nanotechnology and green synthesis strategies provides innovative solutions in biomedicine. This study focuses on the biofabrication of silver nanoparticles (AgNPs) using Corynespora smithii, an endophytic fungus isolated from Bergenia ciliata. The eco-friendly synthesis process employed fungal extracts as [...] Read more.
The integration of nanotechnology and green synthesis strategies provides innovative solutions in biomedicine. This study focuses on the biofabrication of silver nanoparticles (AgNPs) using Corynespora smithii, an endophytic fungus isolated from Bergenia ciliata. The eco-friendly synthesis process employed fungal extracts as reducing and stabilizing agents thereby minimizing the need for hazardous chemicals. The AgNPs demonstrated strong potent biological activities, showcasing significant antioxidant, antibacterial, and anticancer properties. The antibacterial efficacy was demonstrated against various Gram-positive and Gram-negative bacteria, while cytotoxicity on the A549 lung cancer cell line revealed an IC50 value of 10.46 µg/mL. A molecular docking analysis revealed interactions between the major bioactive compound, dimethylsulfoxonium formylmethylide, and the pathogenic proteins, Staphylococcus aureus and Salmonella typhi, displaying moderate binding affinities. Furthermore, the ADME analysis of dimethylsulfoxonium formylmethylide indicated favourable pharmacokinetic properties, including high gastrointestinal absorption, minimal lipophilicity, and low potential for drug–drug interactions, making it a promising candidate for oral drug formulations. These findings further support the compound’s suitability for biomedical applications. This research emphasizes the potential of C. smithii as a sustainable source for synthesizing bioactive nanoparticles, paving the way for their application in developing novel therapeutic agents. This study highlights the significance of harnessing endophytic fungi from medicinal plants for sustainable nanotechnology advancements. Full article
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