Dear Colleagues,

Biological therapies are under rapid development and show paramount importance in human health and public health at this time of a worldwide pandemic. Monoclonal antibody, cell therapy, gene therapy, and vaccine are among the therapy that have rapidly developed in recent years, witnessing thousands of molecules entering clinical trials. These biologics have various forms, including recombinant proteins, viral vector, RNA, and many other modalities. 

Manufacturing processes of these biologics need process engineering, which involves production in a biosystem, purification by physicochemical properties, and analytics that help to understand processes and products. Biomanufacturing processes are challenged by an unmet need to improve process efficiency and control of product quality. Common problems include scale-up, process and product variabilities, suboptimal yields, difficult development, and insufficient process understanding. The key to advancing biomanufacturing is through fundamental studies and innovative technology development.

This Special Issue welcomes the submission of original research and review manuscripts focusing on advancing the manufacturing of biologics with the opportunity to use a range of science and engineering approaches, including systems and synthetic biology, biochemistry, molecular biology, omics, statistical analysis, machine learning, computational biology, mechanical engineering, and many others.

Prof. Dr. Seongkyu Yoon
Dr. Sha Sha
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Biological therapy
• Biomanufacturing
• Product quality
• Process control
• Systems biology
• Computation
• Sensing technology
• Statistical analysis
• Machine learning
• Biological engineering
• Biochemistry
• Mechanical engineering