Mechanisms of Adenovirus Pathogenesis
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Microbiology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 6244
Special Issue Editors
2. Edward Hines, Jr. Veterans Administration Hospital, Hines, IL 60141, USA
Interests: DNA viral gene regulation of mammalian cell responses to injury by inflammatory cells, cytokines and chemotherapeutic drugs; host innate and adaptive immune responses to virally infected and neoplastically transformed cells, as related to viral immunopathogenesis and tumorigenicity
2. Department of Biological Sciences, Boise State University, Boise, ID 83702, USA
Interests: adenoviral gene control of host inflammatory responses to virally infected cells and related modulation of cellular innate immune responses and immunopathogenesis; viral oncogene effects on neoplastically transformed cell susceptibility to antitumor effects of natural killer cells and activated macrophages
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Special Issue Information
Dear Colleagues,
Mammalian adenoviruses, classified in the genus Mastadenovirus, have been characterized for a range of pathogenic traits in their hosts. A few of the seven human adenovirus species have been studied extensively, with the characterization of their genomes, transcription maps, intracellular replication strategies and the biological functions of their gene products. The spectrum of pathologies associated with adenovirus infections is related to host organ targeting (tropism), cellular support of the viral replication cycle (permissiveness), infected cell death responses and multifaceted interactions with host immune responses. This Special Issue will focus on mechanisms by which adenoviral gene expression determines the extent and outcomes of infection-induced cellular changes and immune responses leading to organ pathology. The goals are 1) to add to the understanding of adenoviral genetic control of the host response to viral particles and virally infected cells and organs, to support advances in antiviral therapy, adenovirus-based gene therapy and vaccine development and 2) to develop new strategies that can be used to modulate virus-induced tissue pathology and immunopathogenesis. We welcome reports of original research and topically relevant reviews related to these topics.
Prof. Dr. James L. Cook
Prof. Dr. Jay R. Radke
Guest Editors
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Keywords
- adenovirus
- viral gene
- pathogenesis
- immunopathogenesis
- tissue tropism
- cellular permissiveness
- mammalian species specificity
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