Targeted Degradation for Protein Function Studies
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (15 April 2021) | Viewed by 11762
Special Issue Editors
2. Pasteur Institute, Fondazione Cenci-Bolognetti, 00161 Rome, Italy
Interests: epigenetics and chromatin remodeling; mechanisms of mitosis in drosophila melanogaster and human; meiosis and spermiogenesis in drosophila melanogaster; cytokinesis; floating-harbor syndrome and tubulinopathies
Special Issues, Collections and Topics in MDPI journals
2. Pasteur Institute of Italy, Roma, Italy
Interests: cell cycle and cell division in Drosophila melanogaster and humans; protein phosphorylation; protein degradation technologies; Chromatin remodeling; gametogenesis in Drosophila melanogaster; tubulinopathies and ciliopathies
Special Issue Information
Dear Colleagues,
This Special Issue focuses on the use of advanced protein degradation systems to target a protein of interest, rather than the gene or its mRNA, for rapid degradation. Such experimental strategies overcome any limitations due to use of gene knockout or RNA interference (RNAi) approaches due, respectively, to genetic mutations of essential genes resulting in early death of the organism or off-target effects. Additionally, the latter approach does not affect protein products that are already translated before its induction; therefore, depending on the turnover, the protein of interest could still be functional even if its mRNA is downregulated.
For this Special Issue, I would like to invite authors to submit original research articles that employ targeted protein degradation (TPD) systems to unveil the functional roles of proteins whose study has otherwise been shown to be extremely tricky when applying conventional protein depletion approaches.
Dr. Giovanni Messina
Guest Editor
Manuscript Submission Information
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Keywords
- Targeted Protein Degradation
- Chemically Induced Proteasome-mediated Degradation
- Targeted Displacement for Protein Inactivation
- Piranha Targeted Protein Degradation
- TRIM-Away
- Degron
- Degraders
- AiD
- FKBP12
- HALO
- CRBN
- ANCHOR-Away
- PROTAC
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