Special Issue "Targeted Degradation for Protein Function Studies"

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 31 October 2020.

Special Issue Editor

Dr. Giovanni Messina
Guest Editor
Department of Biology and Biotechnology “Charles Darwin” and Pasteur Institute of Italy, Sapienza University of Rome, 00185 Rome, Italy
Interests: Epigenetics and Chromatin Remodeling; mechanisms of mitosis in Drosophila melanogaster and human; meiosis and spermiogenesis in Drosophila melanogaster; cytokinesis; Floating-Harbor syndrome and tubulinopathies

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the use of advanced protein degradation systems to target a protein of interest, rather than the gene or its mRNA, for rapid degradation. Such experimental strategies overcome any limitations due to use of gene knockout or RNA interference (RNAi) approaches due, respectively, to genetic mutations of essential genes resulting in early death of the organism or off-target effects. Additionally, the latter approach does not affect protein products that are already translated before its induction; therefore, depending on the turnover, the protein of interest could still be functional even if its mRNA is downregulated.

For this Special Issue, I would like to invite authors to submit original research articles that employ targeted protein degradation (TPD) systems to unveil the functional roles of proteins whose study has otherwise been shown to be extremely tricky when applying conventional protein depletion approaches.

Dr. Giovanni Messina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Targeted Protein Degradation
  • Chemically Induced Proteasome-mediated Degradation
  • Targeted Displacement for Protein Inactivation
  • Piranha Targeted Protein Degradation
  • TRIM-Away
  • Degron
  • Degraders
  • AiD
  • FKBP12
  • HALO
  • CRBN
  • ANCHOR-Away

Published Papers

This special issue is now open for submission.
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