Special Issue "Response of Pluripotent Stem Cells to Environmental Stresses"

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 30 April 2021.

Special Issue Editors

Dr. Taku Kaitsuka
Guest Editor
Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Japan
Interests: Stem cells; Stress response; Neuroscience; Neurodevelopmental disorders; Protein synthesis; Gene expression; Trp channels; Pancreatic development
Dr. Farzana Hakim
Guest Editor
Scientist I, Biogen Pharmaceuticals, MA, USA
Interests: Stem Cell Biology; Neuroscience; Gene therapy; Analytical Development; CRISPR-Cas9; Bioassay Development
Dr. Mohd. Raeed Jamiruddin
Website1 Website2
Guest Editor
Department of Pharmacy, Brac University, Bangladesh
Interests: Cancer Biology; Stem cells; Alternate Lengthening of Telomeres; Gene expression; Pancreatic development; Protein synthesis; Protein drug development

Special Issue Information

Dear Colleagues,

In pluripotent stem cells (PSCs) as embryonic and induced pluripotent stem cells (iPSCs), the characteristics as epigenetic state, gene expression profiles, and the cellular localization of  proteins are quite different from differentiated and somatic cells. Due to such differences, the response to environmental stimuli and stresses as hypoxic, heat, and oxidative stress and chemicals, some ligands of channels and receptors etc is also different between PSCs and differentiated cells. For example, PSCs are highly sensitive to proteotoxic stress by MG132 and the levels of stress-responsive transcription factors change during differentiation.

In this special issue, we would like to focus on such difference and the mechanism of it. By clarifying it, we can know the characteristics of stress response of PSCs and set up the differentiation protocol to somatic tissues by considering it. Furthermore, it could serve an useful information for the research on toxicology of chemicals in embryos and on iPSC-derived stress-related disease model like neurodegenerative diseases.

In this special issue, we invite the original research articles and reviews on the following subjects: (1) the molecular mechanism of the response to any stresses in stem cells; (2) the implication of stress response in stemness and differentiation; (3) iPSC-derived stress-ralated disease models and their stress response; (4) toxicology in embryonic stem cells.

Dr. Taku Kaitsuka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Stem cells
  • Stress response
  • Differentiation
  • Heat stress
  • Hypoxic stress
  • Oxidative stress
  • Proteotoxic stress

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Tentative title: Stress response of pluripotent and multipotent stem cells as a medium for directed differentiation
Affiliation: Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Japan
Author: Taku Kaitsuka

Tentative title: Developmental computation with embryonic stem cells
Author: Thomas B. Knudsen
Tentative Abstract: Chemical assessments must consider risks to pregnancy and prenatal development, motivating the need for new models are needed that reflect the best available knowledge of embryology and that can be used to computationally decode the toxicological blueprint of human development. Morphological programming logic of the epiblast provides a platform for computational intelligence that can translate in vitro toxicity data on human embryonic stem cells into a mechanistic hazard prediction for developmental toxicity during early stages in development when the basic body plan is established. Embryonic stem cells (ESCs) are among the most promising in vitro platforms for development hazard identification in place of pregnant animal testing. Vast ESC data now in hand, a multiscale modeling and simulation has the versatility and power to enable developmental computation with ESC data and to translate chemical responses by ESCs into key signaling pathways, cellular behaviors, and critical phenomena.

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