The Role of Gut Microbiota in Human Metabolism and Disease
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: 28 February 2026 | Viewed by 52
Special Issue Editor
Special Issue Information
Dear Colleagues,
The alteration of gut microbiota, including bacteria, fungi, and viruses, that is associated with host conditions and its possible control for health benefits.
The abundance of microorganisms in the gut is surprisingly high, which might be approximately 10-fold higher than that in human cells, with a crucial role in digestion, immune functions, and overall health, while the imbalances in the gut microbiota contribute to several diseases. These microbiota consist of not only bacteria but also fungi, viruses, protozoa, and archaea. The importance of gut microbiota, or normal flora, is increasingly recognizable through the possible connection between the gut and other organs, referred to as “the organ cross-talk”, for example, the gut–liver–kidney axis, the gut–lung axis, and the gut–brain axis. Gut microbiota is surprisingly vulnerable to several factors, including the endogenous micro-environments from the host and exogenous diets. As such, the simple alteration in stress hormones of the host might directly select some population of bacteria that benefit these stress hormones, called stress-induced dysbiosis. Meanwhile, some diets (extremely spicy foods and high-fat diets) directly select the growth of some bacteria over others, resulting in gut dysbiosis. The understanding of this cross-talk might lead to the use of microbiota as a biomarker, while its control using several methods might represent novel strategic treatments for some diseases. Manuscripts addressing these topics are invited for this Special Issue, especially those combining a high academic standard coupled with a practical focus on providing possible use of the data from microbiota.
Dr. Asada Leelahavanichkul
Guest Editor
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Keywords
- microbiota
- bacteriome
- fungiome
- virome
- cross-talk
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