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Biology
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Feature Papers on Toxicology
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Feature Papers on Toxicology

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Toxicology".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 604

Special Issue Editor

Prof. Dr. Hui Xu

E-Mail Website
Guest Editor
School of Marine Sciences, Ningbo University, Ningbo 315832, China
Interests: botanical pesticides; natural bioactive products; isolation; structural modification; structural elucidation; mechanism of action; pesticidal activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue seeks to compile high-quality Feature Papers that delve into the molecular and cellular mechanisms of toxicology. We invite comprehensive reviews and original research articles that explore topics including, but not limited to, the following:

  • Mechanisms of cellular response to toxicants;
  • Organ-specific toxicities and pathophysiological changes;
  • Development and validation of biomarkers for toxicity assessment;
  • Molecular pathways involved in toxin-induced diseases;
  • Advancements in in vitro and in vivo toxicological models;
  • Regulatory aspects and risk assessment in toxicology.

By focusing on these areas, the Special Issue aims to provide a comprehensive overview of current research in toxicology, fostering a deeper understanding of how environmental and chemical exposures impact biological systems. We encourage submissions that offer novel insights, integrate multidisciplinary approaches, and contribute to the advancement of toxicological sciences.

This Special Issue will serve as a valuable resource for researchers and professionals in the field of toxicology, providing a platform for the dissemination of cutting-edge research and facilitating the exchange of knowledge across disciplines.

Prof. Dr. Hui Xu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • toxicology
  • cellular toxicity
  • organ toxicity
  • biomarkers
  • molecular mechanisms
  • in vitro models
  • in vivo models
  • risk assessment
  • environmental exposures
  • chemical toxicology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

16 pages, 2922 KB  
Article
Proteomic Analysis of Liver Injury Induced by Deoxynivalenol in Piglets
by Xiaoshu Xue, Ping Wu, Shuhao Fan, Zongjun Yin and Xiaodong Zhang
Biology 2025, 14(12), 1721; https://doi.org/10.3390/biology14121721 - 1 Dec 2025
Viewed by 224
Abstract
Deoxynivalenol (DON, commonly known as vomitoxin) is one of the most prevalent mycotoxins contaminating feed in China, posing a serious threat to the health of piglets. Beyond intestinal damage, the liver is a key target organ for the systemic toxicity of DON, but [...] Read more.
Deoxynivalenol (DON, commonly known as vomitoxin) is one of the most prevalent mycotoxins contaminating feed in China, posing a serious threat to the health of piglets. Beyond intestinal damage, the liver is a key target organ for the systemic toxicity of DON, but its hepatotoxic molecular mechanisms, particularly the changes at the proteome level, remain unclear. To investigate the protein regulatory network of DON-induced liver injury in piglets, this study systematically analyzed differential expression in the liver proteome using quantitative proteomic techniques. Proteomic analysis identified 5851 proteins in total, among which 88 were differentially expressed proteins (DEPs), including 39 upregulated and 49 downregulated proteins. Bioinformatics analysis revealed that these DEPs were significantly enriched in pathways such as DNA damage repair, RNA metabolism, ribosome biogenesis, and cysteine metabolism. Suppressed expression of key proteins like Replication Factor C Subunit 4 (RFC4) and Exosome Component 9 (EXOSC9) indicated that DON exposure severely disrupted the maintenance of genomic stability and RNA processing capacity in hepatocytes. Conversely, the activation of Nucleic Acid Binding Protein 1 (NABP1) might represent a compensatory DNA protection response. Furthermore, the upregulation of Lactate Dehydrogenase B (LDHB) suggested that DON might influence epigenetic modifications by regulating lactate metabolism. This study reveals, for the first time from a proteomic perspective, a novel mechanism by which DON induces hepatotoxicity in piglets by disrupting DNA repair and RNA metabolic homeostasis, providing an important theoretical basis and data support for elucidating the toxicological effects of DON and improving feed biosafety control strategies. Full article
(This article belongs to the Special Issue Feature Papers on Toxicology)
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18 pages, 5471 KB  
Article
Comparative Analysis of Symbiotic Bacterial Diversity and Sublethal Effects of Nitenpyram Against Two Different Cotton Aphids
by Wenjie Li, Wei Cao, Xuanling Wei, Dongsheng Hu, Kailong Yuan, Renfu Zhang and Yongsheng Yao
Biology 2025, 14(12), 1684; https://doi.org/10.3390/biology14121684 - 26 Nov 2025
Viewed by 228
Abstract
Symbiotic bacteria in insects are known to play crucial roles in detoxification metabolism and adaptation to host plant secondary metabolites. In the cotton-growing region of Xinjiang, China, the Ap. gossypii and the Ac. gossypii exhibit significant differences in sensitivity or resistance to pesticides. [...] Read more.
Symbiotic bacteria in insects are known to play crucial roles in detoxification metabolism and adaptation to host plant secondary metabolites. In the cotton-growing region of Xinjiang, China, the Ap. gossypii and the Ac. gossypii exhibit significant differences in sensitivity or resistance to pesticides. However, whether their detoxification-related symbiotic bacteria change under insecticide stress remains unclear. This study assessed the toxicity of nitenpyram to both aphid species and the effects of LC20 treatment on their growth, development, and reproduction. Bacterial community dynamics across generations (G0–G2) were analyzed by 16S rRNA gene amplicon sequencing. The LC20 of nitenpyram reduced the longevity and fecundity of the parent generation in both species. In Ap. gossypii, the intrinsic rate of increase (rm), net reproductive rate (R0), and finite rate of increase (λ) increased in the G1–G2 generations, whereas these parameters significantly decreased in Ac. gossypii. By the G3 generation, biological parameters in both species showed no significant differences compared to the control. Nitenpyram disrupted the stability of symbiotic bacterial communities in both aphids. In Ac. gossypii, Sphingomonas, a genus with detoxification potential, was consistently suppressed in G1–G2, while the abundance of the primary symbiont Buchnera initially decreased sharply and subsequently recovered. In contrast, the bacterial community in Ap. gossypii remained largely stable. These findings indicate that sublethal concentrations of nitenpyram exert distinct transgenerational effects on the two aphid species and disrupt the stability of their symbiotic bacterial communities. Full article
(This article belongs to the Special Issue Feature Papers on Toxicology)
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