RNA Biology and Roles in Diseases
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 2597
Special Issue Editors
Interests: circRNAs; RNA biology; cardiovascular disease
Special Issue Information
Dear Colleagues,
RNAs play a fundamental role in gene expression, either in the form of protein-coding messenger RNA (mRNA) or as non-coding RNA involved in transcriptional regulation. Recent advances in RNA biology have revealed an unexpected level of diversity and complexity in RNA molecules and cellular RNA metabolism. Studies indicate that RNA biogenesis undergoes significant alterations in various diseases, including cancer, cardiovascular diseases, and neurological disorders. These changes may arise through mutations in genes encoding RNA-processing factors, variations in the expression levels of these factors, or direct modifications at the RNA level.
Elucidating these alterations will enhance our understanding of the molecular mechanisms by which RNAs contribute to disease-related pathways, thereby improving our knowledge of the clinical manifestations and progression of human diseases. However, though significant progress has been made in this area, further research and clarification is needed to ensure that we have a comprehensive understanding of the full spectrum of RNA functions in disease pathogenesis. A deeper insight into these mechanisms is also paramount for the future development of RNA-targeted therapies. As the field of RNA biology continues to expand, it is anticipated that the discovery of novel and evolving roles of RNA in different cellular contexts will improve our comprehension of the development, homeostasis, and pathogenesis of various diseases. Due to the rapid advancements in RNA studies and RNA-related technologies, our knowledge of the relationship between RNA and diseases is constantly evolving, and although there are still many unanswered questions regarding the biology of RNAs and the mechanisms governing their gene regulation, significant advances have been made in this field.
The aim of this Special Issue is to provide a comprehensive overview of the relationship between RNA biology and disease, integrating cutting-edge research on RNA editing mechanisms with innovative applications of RNA therapies, involving both mRNA and non-coding RNA, in the treatment of disease. The Special Issue is specifically focused on innovative approaches to enhancing the efficacy of RNA-based therapies, and studies on gene expression, immunological responses, and therapeutic outcomes are of particular interest.
This Special Issue highlights the key mechanisms underlying RNA functions, the changes involved in RNA biogenesis, and their broader implications. We welcome contributions that advance our understanding of these processes and foster the development of RNA-based therapeutic strategies.
Dr. Nan Wu
Dr. Sema Misir
Guest Editors
Manuscript Submission Information
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Keywords
- RNA biology
- diseases
- circRNA
- mRNA
- non-coding RNA
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