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Biology
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Extracellular Vesicles and Pathophysiology
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Extracellular Vesicles and Pathophysiology

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 28 February 2025 | Viewed by 3778

Special Issue Editor

Dr. Abdel Alli

E-Mail Website
Guest Editor
Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL 32610, USA
Interests: extracellular vesicles; aging; pathophysiology; epithelial transport mechanisms; COVID-19; hypertension; chronic kidney disease; diabetes; cystic fibrosis; sepsis; gastroparesis; hereditary alpha-tryptasemia; pheochromocytoma; aortic coarctation

Special Issue Information

Dear Colleagues,

As the Guest Editor of this Special Issue on “Extracellular Vesicles and Pathophysiology”, I would like to solicit submissions of original research articles and review articles on this particular subject. The papers in this Special Issue should aim to draw attention to the biological significance of extracellular vesicles in the pathophysiology of various diseases.

Extracellular vesicles (EVs) play an important role in physiology and pathophysiology. These vesicles were once thought to only function as the garbage bin of a cell to remove unneeded molecules. However, accumulating evidence clearly shows extracellular vesicles play an important role in the pathogenesis of disease. EVs are being studied in the context of biomarker discovery for the diagnosis and prognosis of various diseases. Moreover, EVs are being used as vehicles for the delivery of various drugs, and therefore, have great therapeutic potential.

The scope of this Special Issue includes the investigation of EVs at multiple levels in the context of normal biological and/or cellular processes being disrupted, leading to the development of disease. Both descriptive and mechanistic studies are welcome, but the research should be novel and not under current consideration for publication in any other journal. Additionally, manuscripts introducing novel methods to investigate various aspects of EVs are welcome.

Dr. Abdel Alli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular vesicles
  • biomarkers
  • diagnostics
  • therapeutics
  • disease mechanism

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Published Papers (2 papers)

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Research

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17 pages, 8149 KiB  
Article
Colorectal Cancer Cell-Derived Extracellular Vesicles Promote Angiogenesis Through JAK/STAT3/VEGFA Signaling
by Yuqing Long, Yuxi Dan, Yao Jiang, Jing Ma, Tao Zhou, Liaoqiong Fang and Zhibiao Wang
Biology 2024, 13(11), 873; https://doi.org/10.3390/biology13110873 - 27 Oct 2024
Viewed by 999
Abstract
Background: Angiogenesis plays a crucial role in the growth of colorectal cancer (CRC). Recent studies have identified extracellular vesicles (EVs) in the tumor microenvironment as important mediators of cell-to-cell communication. However, the specific role and mechanisms of CRC-derived EVs in regulating tumor angiogenesis [...] Read more.
Background: Angiogenesis plays a crucial role in the growth of colorectal cancer (CRC). Recent studies have identified extracellular vesicles (EVs) in the tumor microenvironment as important mediators of cell-to-cell communication. However, the specific role and mechanisms of CRC-derived EVs in regulating tumor angiogenesis remain to be further investigated. Methods: EVs were isolated from the conditioned medium of the CRC cells using ultracentrifugation. We investigated the effects of HT-29-derived EVs on tumor growth and angiogenesis in a subcutaneous HT-29 CRC tumor model in mice. Additionally, we evaluated the impact of HT-29-derived EVs on the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs). Subsequently, bioinformatics analysis was performed to identify relevant signaling pathways, and pathway inhibitors were used to block the activation of these pathways, aiming to elucidate their roles in angiogenesis. Results: We found that HT-29-derived EVs can promote tumor growth and angiogenesis in vivo, as well as significantly enhance the proliferation, migration, and tube formation of HUVECs. Bioinformatics analysis revealed that HT-29-derived EVs may regulate angiogenesis through the JAK/STAT3 signaling pathway. Specifically, we observed that CRC-derived EVs promoted the phosphorylation of STAT3 (p-STAT3) and the expression of VEGFA in the nucleus of HUVECs. Treatment with the STAT3 inhibitor Stattic reduced the nuclear expression of p-STAT3, which impaired its function as a transcription factor, thereby inhibiting VEGFA expression and the pro-angiogenic effects of CRC-derived EVs. Conclusions: EVs derived from CRC cells promote CRC tumor angiogenesis by regulating VEGFA through the JAK/STAT3 pathway in endothelial cells. Full article
(This article belongs to the Special Issue Extracellular Vesicles and Pathophysiology)
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Review

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14 pages, 1023 KiB  
Review
Extracellular Vesicles: Investigating the Pathophysiology of Diabetes-Associated Hypertension and Diabetic Nephropathy
by Abdel A. Alli
Biology 2023, 12(8), 1138; https://doi.org/10.3390/biology12081138 - 16 Aug 2023
Cited by 1 | Viewed by 2258
Abstract
Extracellular vesicles (EVs) include exosomes, microvesicles, and apoptotic bodies. EVs are released by all cell types and are found in biological fluids including plasma and urine. Urinary extracellular vesicles (uEVs) are a mixed population of EVs that comprise small EVs that are filtered [...] Read more.
Extracellular vesicles (EVs) include exosomes, microvesicles, and apoptotic bodies. EVs are released by all cell types and are found in biological fluids including plasma and urine. Urinary extracellular vesicles (uEVs) are a mixed population of EVs that comprise small EVs that are filtered and excreted, EVs secreted by tubular epithelial cells, and EVs released from the bladder, urethra, and prostate. The packaged cargo within uEVs includes bioactive molecules such as metabolites, lipids, proteins, mRNAs, and miRNAs. These molecules are involved in intercellular communication, elicit changes in intracellular signaling pathways, and play a role in the pathogenesis of various diseases including diabetes-associated hypertension and diabetic nephropathy. uEVs represent a rich source of biomarkers, prognosis markers, and can be loaded with small-molecule drugs as a vehicle for delivery. Full article
(This article belongs to the Special Issue Extracellular Vesicles and Pathophysiology)
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