Special Issue "Cytokines and Chemokines: Modulators of Epithelial Cell Biology in Health and Disease"

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".

Deadline for manuscript submissions: 15 October 2022 | Viewed by 1268

Special Issue Editors

Prof. Dr. Barry James Campbell
E-Mail Website
Guest Editor
Gastroenterology Research Unit, Department of Infection Biology & Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health & Life Sciences, University of Liverpool, Liverpool L69 3GE, UK
Interests: gut secretory cell biology; epithelial glycobiology; bacteria-host interaction in inflammation and cancer; intestinal microbiota
Dr. Stamatia Papoutsopoulou
E-Mail Website
Guest Editor
Department of Biochemistry and Biotechnology, School of Health Sciences, University of Thessaly, Viopolis, 41500 Larissa, Greece
Interests: mucosal immunology and inflammation; epithelial biology; innate immune responses; cytokine signal transduction pathways; transcriptional regulators; NFkappaB

Special Issue Information

Dear Colleagues,

It is well established that epithelial surfaces are responsible for protection, in the intestine for  absorption of nutrients and prevention of inflammatory conditions induced by exogenous factors, such as the  associated microbiota, and foreign and/or dietary antigens. This is achieved by maintenance of a physical barrier, synthesis of a mucus layer, secretion of antimicrobial peptides and active engagement in immune cell regulation to facilitate the internalisation, processing and efficient presentation of antigens. Cytokines and chemokines can have pro- and anti-inflammatory actions and can positively or negatively affect epithelial cell proliferation, cell death and barrier permeability. During inflammation and/or cancer, there is an increased mobilisation and activation of immune cells, the barrier integrity is compromised and there is an increasing tissue destruction. Chemokines that belong to a constitutive or homeostatic group mostly play an important role in the development and organisation of associated lymphoid tissue. On the other hand, inducible chemokines and cytokines are secreted in a response to proinflammatory signals and play a crucial role in epithelial inflammation and its resolution, and their dysregulation has been linked to stress, infection, inflammatory disease, cancer and inflammation-associated damage.

In this Special Issue, we propose highlighting recent advances in our understanding of how cytokines and chemokines, both those made by and those acting on the  epithelium, orchestrate many of the diverse functions of the different specialised epithelial cell types and their interactions with cells of the innate immune system (such as dendritic cells, macrophages, monocytes and neutrophils), both in health and disease.

We welcome manuscripts particularly focused on the intrinsic role of epithelial cell-derived cytokines and chemokines, as this is an area that is still poorly understood.

Prof. Dr. Barry James Campbell
Dr. Stamatia Papoutsopoulou
Guest Editors

Manuscript Submission Information

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Keywords

  • cytokine
  • chemokine
  • epithelium
  • mucosal immunology
  • epithelial homeostasis
  • infection
  • stress
  • inflammation and cancer

Published Papers (1 paper)

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Research

Article
Interleukin-27 Regulates the Function of the Gastrointestinal Epithelial Barrier in a Human Tissue-Derived Organoid Model
Biology 2022, 11(3), 427; https://doi.org/10.3390/biology11030427 - 11 Mar 2022
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Abstract
A treatment with direct healing effects on the gastrointestinal epithelial barrier is desirable for inflammatory bowel disease (IBD). Interleukin-27 (IL-27) is an immunoregulatory cytokine, and oral delivery is an effective treatment in murine models of IBD. We aimed to define IL-27 effects on [...] Read more.
A treatment with direct healing effects on the gastrointestinal epithelial barrier is desirable for inflammatory bowel disease (IBD). Interleukin-27 (IL-27) is an immunoregulatory cytokine, and oral delivery is an effective treatment in murine models of IBD. We aimed to define IL-27 effects on the human gastrointestinal epithelial barrier. We characterised gene and protein expression of permeability mediators in a human colon-derived organoid model. Functional permeability was determined in an organoid-derived 2D monolayer by transepithelial electrical resistance. IL-27 effects on epithelial innate immune responses were assessed through expression of cytokines, anti-microbial peptides and MUC genes. IL-27 effects on wound healing and proliferation were determined in human colon epithelial cell lines. IL-27 led to restoration of permeability regulation following inflammatory cytokine insult (p = 0.001), associated with differential expression of tight junction mediators with decrease in claudin 2 (p = 0.024) and increase in claudin 4 (p < 0.001), E-cadherin (p < 0.001) and zona occludens (p = 0.0014). IL-27 evoked differential gene expression of epithelial-derived innate immune responses (reduced IL1B and IL18, and increased IL33, HBD1, MUC1 and MUC2; p < 0.012). IL-27 induced epithelial barrier wound healing through restitution (p < 0.001), and increased proliferation (p < 0.001) following injury. Overall, IL-27 provokes mucosal healing of the human gastrointestinal epithelial barrier. Full article
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