Recent Advances in Intrahepatic Cholangiocarcinoma: Shedding Light on Clinical and Genetic Heterogeneity

Dear Colleagues, 

Cholangiocarcinoma (CCA) is a malignant neoplasm arising in the epithelium of the biliary tract. It represents the second most common primary liver cancer in the world, after hepatocellular carcinoma. CCAs are divided into intrahepatic and extrahepatic tumors according to their anatomic location. The incidence of intrahepatic CCA (iCCA) is increasing particularly in Western countries and most patients present with locally advanced or metastatic disease (involving mainly lymph nodes, peritoneum, and liver). However, in these cases, the prognosis is dismal because of low responsiveness to standard chemotherapies. Recent studies have revealed marked genetic heterogeneity underlying the development and progression of iCCA. For these reasons, iCCA is a good model for studying new putative druggable biologic pathways in cancer.

The present Special Issue is proposed to prompt scientific insights into:

• Emerging biologic pathways involved in iCCA establishment and/or progression;
• Prognostic and/or predictive role of specific phenotypic and/or genotypic features of iCCA;
• Precision medicine in iCCA.

Original articles and reviews are the preferred editorial target of this Special Issue. Analyses consisting exclusively of bioinformatics or computational analyses of public databases will not be considered.

Dr. Guglielmo Nasti
Dr. Alessandro Ottaiano
Guest Editors

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